Role of the insulin-like growth factor 1 receptor signaling pathway in the pathogenesis of related skin diseases

Hongyan TANG; Bin XIAO; Guilan YANG

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Role of the insulin-like growth factor 1 receptor signaling pathway in the pathogenesis of related skin diseases

VernacularTitle: 胰岛素样生长因子1受体信号通路在相关皮肤病发病机制中的作用
Author: Hongyan TANG ¹ ; Bin XIAO ² ; Guilan YANG ³
Author Information

1. Department of Dermatology, Lanzhou University Second Hospital, Lanzhou 730000, China
2. Department of Dermatology, Changshu No.5 People′s Hospital, Changshu 215500, Jiangsu, China
3. Department of Cosmetic Dermatology and Venereology, Shenzhen Hospital of Southern Medical University, Shenzhen 518000, China
Publication Type:Review
Keywords: Insulin-like growth factor Ⅰ; Phosphatidylinositol 3-kinases; MAP kinase signaling system; Skin diseases
From: Chinese Journal of Dermatology 2019;52(12):934-936
CountryChina
Language:Chinese
Abstract: After binding to the specific insulin-like growth factor 1 receptor (IGF1R) on the surface of target tissue cells, IGF can regulate physiological processes such as apoptosis, proliferation and senescence, which are closely related to growth and development of the body, and occurrence and development of diseases. The binding between IGF1 and IGF1Rα can cause conformational changes of the beta subunit of IGF1R, lead to activation of receptor tyrosine kinase, initiation of the downstream phosphatidylinositol 3-kinase pathway and mitogen-activated protein kinase pathway, and finally participate in the occurrence of acne, psoriasis and other skin diseases. This review summarizes research advances in the role of the IGF1R signaling pathway in the pathogenesis of related skin diseases.