Facilitating the continuous decline on the incidence rates of hepatitis B and liver cancer through cutting off the mother-to-child viral transmission, based on the "prevention first" strategy, in China
10.3760/cma.j.issn.0254-6450.2019.12.027
- VernacularTitle: 通过"预防为主"切断母婴传播促进我国乙型肝炎和肝癌发病率持续下降
- Author:
Shunzhang YU
1
Author Information
1. School of Public Health, Fudan University, Shanghai 200032, China
- Publication Type:Journal Article
- Keywords:
Mother-infant-transmission;
Hepatocellular carcinoma;
Elimination viral hepatitis and control of HCC
- From:
Chinese Journal of Epidemiology
2019;40(12):1650-1653
- CountryChina
- Language:Chinese
-
Abstract:
There have been 6-10 million reported patients with chronic hepatitis B virus (HBV) infection worldwide, and the United Nations (UN) called for a "90% reduction by 2030" strategy. Since the wide practice of HBV vaccination, the numbers of HBV cases have been reduced by 85% and the incidence of hepatocellular carcinoma has also decreased by 50%. As formulated by the UN in 2015, the sustainable development agenda for the eradication of hepatitis B included the success rate of preventing mother-to-child viral transmission by 95%, together with the reduction of new hepatitis B infections by 90% in 2030. In order to achieve the agenda, we proposed a strategy to achieve the "three 96%" goals derived from the Shanghai experience. In brief, hepatitis B vaccine should cover for 96% newborns within 24 h, and the vaccination boosting rate should reach 96% for both one and six months after birth. If cutting off the mother-to-child viral transmission strategy can be successfully achieved, the future of hepatitis B prevention will be promising, and the task of eliminating hepatitis B and controlling hepatocellular carcinoma can be completed ahead of 2030, time proposed by the UN.
