The mediation mechanism of coronary artery lesions in both male and female patients with Kawasaki disease
10.3760/cma.j.issn.0254-6450.2019.12.024
- VernacularTitle: 不同性别川崎病患儿冠状动脉损害风险差异的内在机制
- Author:
Yihan ZHANG
1
;
Rongzhou WU
2
;
Junyong HU
3
;
Zengyou JIN
4
;
Zehao YE
1
;
Huixian QIU
2
;
Maoping CHU
2
;
Hongying SHI
1
Author Information
1. Department of Preventive Medicine, School of Public Health and Management, Wenzhou Medical University, Wenzhou 325035, China
2. The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou 325027, China
3. Wenzhou Medical University, Wenzhou 325035, China
4. The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China
- Publication Type:Clinical Trail
- Keywords:
Kawasaki disease;
Coronary artery lesions;
Mediation analysis
- From:
Chinese Journal of Epidemiology
2019;40(12):1634-1638
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the mediation mechanism of coronary artery lesion among both male and female Kawasaki disease (KD) children.
Methods:Children with KD that hospitalized in the Wenzhou Medical University affiliated Yuying Children’s Hospital from January 2009 to December 2014, were included in this study. Differences on demographical characteristics, clinical manifestations, laboratory indicators, regimen and time of treatment, results from pre/post echocardiography and treatment between male and female patients, were compared. The independent effect of gender on the risk of coronary artery lesions (CAL) was evaluated, and the mediating effect of BMI, visiting time and KD type on the association between gender and CAL were also studied.
Results:The average BMI level of male patients was higher than that of female patients. The difference was statistically significant (P<0.001). The prevalence of overweight among male patients (20.9%) was higher than female (14.1%). The difference was statistically significant (P=0.011). Data from the multivariate logistic regression analysis confirmed that the incidence of CAL in male patients was higher than that in female patients (aOR=1.50, 95%CI: 1.06-2.12) but the CAL was mainly different before on the immunoglobulin therapy. Results from the mediation analysis showed that BMI was an important mediator in the association between gender and CAL, with the indirect effect as 1.05 (95%CI: 1.01- 1.10) and the proportion mediated as 13.0%.
Conclusions:Male patients presented higher incidence of CAL but was mainly reflected in the difference of CAL before the treatment. BMI was probably an important mediator related to the association between gender and CAL.
