Study on the characteristics of major birth defects in 1.69 million cases of fetus in Guangxi Zhuang Autonomous Region
10.3760/cma.j.issn.0254-6450.2019.12.009
- VernacularTitle: 广西壮族自治区169万例胎儿总出生缺陷与重大出生缺陷分布特征研究
- Author:
Baiqing DONG
1
;
Biyan CHEN
2
;
Qiuyu LIANG
3
;
Sheng HE
2
;
Wei LYU
3
;
Botong LIU
3
;
Yangjin ZUO
2
;
Li LIN
2
;
Hui WEI
2
;
Jie WEI
2
;
Xiuning HANG
2
;
Xiaoxia QIU
2
Author Information
1. School of Public Health Management, Guangxi University of Traditional Chinese Medicine, Nanning 530200, China
2. Guangxi Zhuang Autonomous Region Women and Children Care Hospital, Nanning 530000, China
3. Guangxi Zhuang Autonomous Region Health and Family Planning Statistics Information Center, Nanning 530021, China
- Publication Type:Journal Article
- Keywords:
Big data;
Pregnancy outcome;
Birth defects ordering;
Medical intervention;
Effectiveness analysis
- From:
Chinese Journal of Epidemiology
2019;40(12):1554-1559
- CountryChina
- Language:Chinese
-
Abstract:
Objective:Tracking the information on 1.69 million fetal cases across Guangxi Zhuang Autonomous Region (Guangxi) so as to study the occurrences of total and major birth defects in order to evaluate the ability on related prevention and control programs in Guangxi.
Methods:Using the self-developed "Gui Women’s System" to establish a database of 1.69 million fetal cases in Guangxi and to analyze the distribution of time, space and population, as well as the outcomes of pregnancy, using the big data.
Results:During the 29 months of observation, the overall live birth rate was 99.25%, with stillbirth rate during pregnancy as 0.44%, stillbirth rate during birth as 0.02%, and the 0-6 days mortality rate as 0.14%. The total detection rate on birth defects was 197.63/10 000; the incidence rate was 103.04/10 000, the birth rate was 102.55/10 000. The overall discovery rate of major birth defects was 48.33/10 000, with the incidence rate as 783 000, the birth rate as 0.58/10 000. The discovery rates of major birth defects in 14 cities were between 35 and 68/10 000, and the birth rate dropped significantly to less than 1.00 in 10 000. Nationalities showed that the number of pregnant women with birth defects more than 50 000 would include Hui (9.68/10 000), Yao (9.57/10 000), and Jing (9.37/10 000). With the increasing age of gestation, number of birth defects, incidence of major birth defects also increased. Ninety-five percent of the major birth defects were found within <28 weeks and with the top 5 kinds of major birth defects as complicated congenital heart disease (9.11/10 000), alpha thalassemia (8.36/10 000), and 21-trisomy syndrome (7.85/10 000), beta thalassemia (5.32/10 000) and fetal edema syndrome (4.92/10 000). The top 5 major birth defects appeared as complicated congenital heart disease (9.11/10 000), alpha thalassemia (8.36/10 000), and 21-trisomy syndrome (7.85/10 000), beta thalassemia (5.32/10 000) and fetal edema syndrome (4.92/10 000).
Conclusion:Programs leading to increase the rate on discovery of major birth defects were fundamental in effectively reducing the major birth defects.
