Research progress of aldosterone detection methods and clinical applications
10.3760/cma.j.issn.1009-9158.2019.12.018
- VernacularTitle: 醛固酮检测方法及临床应用进展
- Author:
Jingyu QIAN
1
;
Xiangyi LIU
Author Information
1. Department of Clinical Laboratory, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China
- Publication Type:Review
- Keywords:
Aldosterone;
Radioimmunoassay;
Enzyme-linked immunosorbent assay;
Mass spectrometry
- From:
Chinese Journal of Laboratory Medicine
2019;42(12):1072-1077
- CountryChina
- Language:Chinese
-
Abstract:
Aldosterone is a steroid hormone that acts on the kidneys to maintain the balance of sodium and water. Primary hyperaldosteronism (PA) is the most common disease that causes secretory hypertension. PA is often unrecognized and is associated with a high death rate. The aldosterone/rein rate (ARR) and detection of serum or urinary aldosterone are the most effective method to screen and identify PA. In healthy individuals, aldosterone concentration is present in low quantities in serum and there are numerous compounds that can potentially interfere with analysis making aldosterone a technically challenging analyte quantifying method. At present, the method of aldosterone detection includes radioimmunoassay, enzyme-linked immunosorbent assay, chemiluminescence method and mass spectrometry. These methods have their own advantages and disadvantages, the ARR ratios of different detection methods for the diagnosis of PA are not completely consistent. In this paper, the detection methods and clinical applications of aldosterone are reviewed.
