Progress of the functions and active mechanisms of sepsis associated microRNAs and their diagnostic value
10.3760/cma.j.issn.1009-9158.2019.12.007
- VernacularTitle: 脓毒症相关微小RNA标志物功能机制研究进展与诊疗价值
- Author:
Hong MU
1
;
Lei YANG
Author Information
1. Department of Clinical Laboratory, the First Centre Hospital, Tianjin 300192, China
- Publication Type:Journal Article
- Keywords:
Sepsis;
Microrna;
Function;
Mechanism;
Diagnosis and therapy
- From:
Chinese Journal of Laboratory Medicine
2019;42(12):1007-1013
- CountryChina
- Language:Chinese
-
Abstract:
Sepsis is a syndrome encompassing a uncertain pathobiology and threatens the health of human being. The new definition of sepsis indicates that sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. The exacerbation of inflammation accompanied with dysregulation of immunosuppression leads to the complicated changes of pathophysiology in sepsis. MicroRNAs (miRNAs) perform vital roles in the regulations of inflammation responses as well as organ damages associated with sepsis. The variety in the expression level of miRNA appears in the development of sepsis; monitoring and analyzing miRNA levels contributes to the diagnosis and prognosis of the disease. Controlling the expression levels of miRNAs related with sepsis is able to alleviate the organ damages and dysfunctions caused by the disease.
