Value of complement system in the diagnosis of systemic lupus erythematosus
10.3760/cma.j.issn.1009-9158.2019.12.006
- VernacularTitle: 补体系统在系统性红斑狼疮诊疗中的价值
- Author:
Haizhou ZHOU
1
;
Xiuru GUAN
Author Information
1. Department of Laboratory Diagnosis, the First Affiliated Hospital of Harbin Medical University, Harbin 150001, China
- Publication Type:Journal Article
- Keywords:
Lupus erythematosus, systemic;
Complement system proteins;
Complement activation;
Biomarkers
- From:
Chinese Journal of Laboratory Medicine
2019;42(12):1002-1006
- CountryChina
- Language:Chinese
-
Abstract:
The complement system plays a major role in systemic lupus erythematosus (SLE). At present, complement component 3(C3) and component 4(C4) are the diagnostic markers in the internationally recognized standard of SLE classification. Complement C3 and C4 can play a role in the diagnosis of SLE patients, but they are not very specific diagnostic markers. Therefore, it is important to find more better biomarkers of SLE. In this review, the latest findings in complement-focused research in SLE were explored. Complement level, cell-bound complement activation products and membrane-bound complement regulatory proteins are associated with the pathogenesis of SLE. They may become SLE biomarkers and aid the diagnosis and monitoring of patients with this disease.
