The role and progress of complement activation in antiphospholipid syndrome
10.3760/cma.j.issn.1009-9158.2019.12.003
- VernacularTitle: 补体激活在抗磷脂综合征中的作用及研究进展
- Author:
Xiaohui CHEN
1
;
Tiannan ZHANG
;
Liyan CUI
Author Information
1. Department of Laboratory Medicine, Peking University Third Hospital, Beijing 100191, China
- Publication Type:Journal Article
- Keywords:
Complement activation;
Antiphospholipid syndrome;
Complement system proteins;
Biomarkers
- From:
Chinese Journal of Laboratory Medicine
2019;42(12):990-993
- CountryChina
- Language:Chinese
-
Abstract:
Antiphospholipid syndrome(APS) is a non-inflammatory autoimmune disease caused by anti-phospholipid antibodies. In recent years, it has been found that over-activation of complement is the key factor leading to the formation of thrombosis and pathological pregnancy in APS. With more understanding of the role of complement activation in the pathogenesis of APS, methods of complement inhibition therapy have emerged one after another. Therefore, the detection of complement components is of great significance for the early diagnosis, treatment and monitoring of APS.
