Clinical value of complements detection in pregnancy related thrombotic microangiopathy
10.3760/cma.j.issn.1009-9158.2019.12.002
- VernacularTitle: 补体检测在妊娠相关血栓性微血管病诊治中的价值
- Author:
Yingdong HE
1
;
Feng YU
2
Author Information
1. Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing 100034, China
2. Department of Nephrology, Peking University First Hospital, Beijing 100034, China
- Publication Type:Editorial
- Keywords:
Pregnancy complications;
Thrombotic microangiopathies;
Complement activation;
Complement system proteins
- From:
Chinese Journal of Laboratory Medicine
2019;42(12):986-989
- CountryChina
- Language:Chinese
-
Abstract:
Thrombotic microangiopathy (TMA) is an acute clinico-pathological syndrome with varied reasons. Pregnancy related-TMA includes pregnancy associated thrombotic thrombocytopenic purpura (TTP), postpartum hemolytic-uremic syndrome (pHUS), severe preeclampsia (SPE) and Hemolysis, Elevated Liver enzymes and Low Platelet syndrome (HELLP syndrome) and the outcomes are severe. Aberrant activation of complement system plays an important role in the pathogenesis of these diseases. Although these diseases have similar clinical appearance, their pathogenesis, diagnostic and therapeutic methods are different. Precision diagnosis of these diseases to select targeted treatment will greatly improve the prognosis of these patients. Herein, the value of complement system components in the diagnosis and treatment of pregnancy-related TMA are introduced.
