Promotion of wound healing via regulating the polarization of macrophage by mesenchymal stem cells
10.3760/cma.j.issn.1009-4598.2019.12.023
- VernacularTitle: 间充质干细胞诱导巨噬细胞极化促进创面愈合的研究进展
- Author:
Lu WANG
1
;
Jianying GU
;
Chuanyuan WEI
;
Wenjie LUAN
Author Information
1. Department of Plastic and Reconstructive Surgery, Zhongshan Hopsital, Fudan University, Shanghai 200032, China
- Publication Type:Review
- Keywords:
Mesenchymal stem cells;
Macrophage;
Wound healing
- From:
Chinese Journal of Plastic Surgery
2019;35(12):1275-1278
- CountryChina
- Language:Chinese
-
Abstract:
How to promote rapid wound healing and reduce scar hyperplasia is an urgent problem to be solved in plastic surgery. Mesenchymal stem cells (MSCs) is a research hotspot in current cell therapy. The author reviewed the literature and summarized the mechanism of the MSCs effect on the macrophage. MSCs release multiple soluble cytokines, leading the polarization of anti-inflammatory type M2 cell which can reduce the inflammatory cytokines and promote tissue repair and regeneration.The writer concluded that the polarization effect of mesenchymal stem cells on macrophages provides a new therapeutic strategy and theoretical basis for solving the problem of wound healing.
