The effect of unipolar radiofrequency and fractional CO2 laser on hyaluronic acid fillers in a rat model
10.3760/cma.j.issn.1009-4598.2019.12.003
- VernacularTitle: 单极射频及点阵CO2激光对大鼠真皮下注射透明质酸体积的影响
- Author:
Yongqiang FENG
1
;
Lyuping HUANG
1
;
Jianjun WEI
2
;
Yuanyuan GUAN
1
Author Information
1. Laser Aesthetic Center, Plastic Surgery Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100144, China
2. Bejing Yike Medical Aesthetic Hospital, Beijing 100012, China
- Publication Type:Journal Article
- Keywords:
Rat;
Fractional CO2 laser;
Radiofrequency;
Hyaluronic acid
- From:
Chinese Journal of Plastic Surgery
2019;35(12):1178-1184
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the effect of monopolar radiofrequency(RF) and fractional CO2 laser on the filler hyaluronic acid (HA) injected subcutaneously in rats.
Methods:Five circular areas with a diameter of 2 cm at the dorsum of each rat were prepared for different treatment randomly: (1)HA injection group(HA). (2)HA injection+ fractional CO2 laser treatment group(HA+ CO2). (3)HA injection+ radiofrequency treatment group(HA+ RF). (4)0.9%NaCl+ fractional CO2 laser treatment group(NaCl+ CO2). (5)0.9%NaCl+ radiofrequency treatment group(NaCl+ RF). The volume of HA in group 1, 3, 4 were determined via MRI with reconstruction of Mimics Research X 17.0 before or 1, 3, 6, 12 months after photoelectric treatment. The rates of absorption of each time point and duration were calculated.
Results:The mass of HA could be even recognized 12 months after treatment macroscopicly. Inflamatory cell infiltration and fibring were observed around HA in HA, HA+ RF, HA+ CO2 group within 1 month. The fibrous capsule formed around HA, which was enhanced by RF and CO2 laser therapy since 3 months post therapy. There was no significant difference of volume of HA among the three groups before photoelectric treatment. There was significant difference of HA volume on 12 months post treatment, HA(311.90±52.59) μl, HA+ RF(404.80±64.29) μl, HA+ CO2(357.60±59.10) μl(P<0.01). The volume of HA received RF treatment degraded more slowly. The rate of HA absorption during 3-6 months post treatment was significantly lower than that of 6-12 months post treatment(P<0.05).
Conclusions:Fractional CO2 laser and radiofrequency do not increase the degradation of HA. On the contrary, they may prolong the duration of HA injected subcutaneously in rat.
