Effects of autophagy on radiosensitivity
10.3760/cma.j.issn.1004-4221.2019.12.017
- VernacularTitle: 自噬对放射敏感性的影响
- Author:
Guanchu SONG
1
;
Dan LIU
;
Genyan GUO
;
Yuxia ZHAO
Author Information
1. Department of Radiation Oncology, Fourth Affiliated Hospital of China Medical University, Shenyang 110032, China
- Publication Type:Review
- Keywords:
Autophagy;
Neoplasm/radiotherapy
- From:
Chinese Journal of Radiation Oncology
2019;28(12):953-956
- CountryChina
- Language:Chinese
-
Abstract:
Autophagy extensively exists in eukaryotes, which utilizes lysosomes to degrade the damaged organelles or proteins, maintain the stability of the intracellular environment and provide energy. It can also participate in the growth, proliferation and apoptosis of tumor cells through autophagy-related genes and signaling pathways. Radiotherapy is one of the main treatments for cancer, whereas tumor cells often have radiation resistance, which reduces the clinical efficacy. Previous studies have demonstrated that autophagy is associated with the radiosensitivity of tumor cells, but the conclusions are different. In this article, different effects of autophagy upon the radiosensitity of tumor cells were reviewed.
