Analysis of MRI radiomic features of hypoxic area in nasopharyngeal carcinoma patients
10.3760/cma.j.issn.1004-4221.2019.12.010
- VernacularTitle: 鼻咽癌乏氧区MRI影像组学特征分析
- Author:
Xudong KONG
1
;
Tengxiang LI
2
;
Guanzhong GONG
2
Author Information
1. Department of Radiation Oncology, Jiangnan University Hospital (Wuxi City Fourth People′s Hospital), Wuxi 214062, China
2. Department of Radiation Oncology, Shandong Cancer Hospital, Ji′nan 250000, China
- Publication Type:Journal Article
- Keywords:
Nasopharyngeal neoplasm hypoxic area;
Radiomics;
Hypoxic area identification
- From:
Chinese Journal of Radiation Oncology
2019;28(12):924-927
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the magnetic resonance imaging (MRI) radiomic performance of hypoxic area in nasopharyngeal carcinoma patients, aiming to provide a reference for identification and analysis of hypoxic area.
Methods:The MRI-T1, MRI-T2, MRI-T1+ and PET/CT images of 32 patients initially diagnosed with nasopharyngeal carcinoma were retrospectively analyzed. The gross tumor volume (GTV) of nasopharynx was countoured and the hypoxic areas (GTV-H) were identified by 18F-FMISO-PET images. The non-hypoxic areas (GTV-NH) were defined as the rest of areas removed GTV-H from GTV. The radiomic features of GTV-H and GTV-NH were extracted and compared.
Results:The average volume of GTV-H and GTV-NH was (10.92±11.02) cm3 and (7.21±5.70) cm3, respectively. The maximum rate of change was 46% for intensity direct-global min (ID-GM) on MRI-T1(P<0.05, AUC>0.7 and Youden index>0.5). The average rate of change was 136% for long run emphasis (LRE), long run high gray level emphasis (LRHGLE) and long run low gray level emphasis (LRLGLE) on MRI-T2(P<0.05, AUC>0.7 and Youden index>0.5). The high change rates was greater than 90% on MRI-T1+ (P<0.05, AUC>0.7 and Youden index>0.5) for ID-GM, LRE, LRHGLE and LRLGLE.
Conclusions:The hypoxic area of tumor target can be reflected by MRI radiomics on T1/T2/T1+ . Quantifying and tracking the variations of these features can bring benefit to recognize the hypoxic area of nasopharyngeal carcinoma tumor target.
