The value of gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid enhanced T1 mapping MRI in the quantitative evaluation of hepatic fibrosis in patients with hepatitis B
10.3760/cma.j.issn.1005-1201.2019.12.011
- VernacularTitle: 钆塞酸二钠增强MR T1 mapping成像定量评估乙型肝炎肝纤维化的价值
- Author:
Tian QIU
1
;
Zhanqing ZHANG
2
;
Weibo CHEN
3
;
Yangqing HUANG
4
;
Rengyin ZHANG
1
;
Yuxin SHI
1
;
Wen YE
1
;
Xiudong SHI
1
;
Jian LU
5
Author Information
1. Department of Radiology, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China
2. Department of Hepatology, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China
3. Philips Healthcare, Shanghai 200040, China
4. Department of Hepatobiliary Surgery, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China
5. Department of Radiology, Third People′s Hospital of Nantong, Nantong 226006, China
- Publication Type:Journal Article
- Keywords:
Hepatic fibrosis;
Magnetic resonance imaging;
Gadoxetate acid disodium;
T1 mapping
- From:
Chinese Journal of Radiology
2019;53(12):1081-1085
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the quantitative evaluation efficiency of gadolinium- ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) enhanced T1 mapping in staging hepatic fibrosis caused by viral hepatitis B.
Methods:One hundred and fifty patients with chronic hepatitis B were prospectively enrolled in Shanghai Public Health Clinical Center, Fudan University from August 2016 to August 2018.These patients underwent liver aspiration biopsy were divided into four subgroups: S1 (n=38), S2 (n=30), S3 (n=33), S4 (n=49) according to Scheuer-Ludwig scoring system. Non-enhanced and Gd-EOB-DTPA-enhanced MRI were performed in all subjects. Look-Locker sequences were performed to acquire T1 mapping of pre and post-contrast at 20 minutes after Gd-EOB-DTPA administration. The T1 value after 20 minutes of Gd-EOB-DTPA administration (T1 20 min), the reduction rate of T1 value (ΔT1 20 min%), the increase of 1/T1 value (ΔR1 20 min%) were measured and calculated. The one-way ANOVA was applied to compare the difference in T1 20 min, ΔT1 20 min%, ΔR1 20 min% of various fibrosis stages. ROC curves were used to assess the efficacy of T1 20 min, ΔT1 20 min%, ΔR1 20 min% for diagnosing ≥ S2, ≥ S3, ≥ S4. P<0.05 was considered to be statistically significant.
Results:The T1 20 min raised with fibrosis stage increased, ΔT1 20 min% and ΔR1 20 min% reduced with fibrosis stage increased. Areas under the curves of T1 20 min, ΔT1 20 min%, ΔR1 20 min% for diagnosing ≥ S2 were 0.844, 0.905, 0.869; and diagnosing ≥ S3 were 0.832, 0.907, 0.862; and diagnosing ≥ S4 were 0.853, 0.897, 0.873, respectively. The diagnostic efficiency of ΔT1 20 min% was the best.
Conclusion:Gd-EOB-DTPA-enhanced T1 mapping could be regarded as a reliable diagnostic tool for the evaluation of hepatic fibrosis caused by viral hepatitis B.
