Dosimetric comparison of two radiotherapy treatment planning approaches for multiple brain metastases from non-small cell lung cancer on CyberKnife
10.3760/cma.j.issn.0254-5098.2019.12.009
- VernacularTitle: 非小细胞肺癌多发脑转移射波刀放疗的不同计划设计方案分析
- Author:
Xuyao YU
1
;
Zhiyong YUAN
;
Fengtong LI
;
Yang DONG
;
Yongchun SONG
;
Xiaoguang WANG
;
Ping WANG
Author Information
1. Department of Radiotherapy, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin′s Clinical Research Center for Cancer
- Publication Type:Journal Article
- Keywords:
CyberKnife;
Multiple brain metastases;
Treatment Plan;
Dosimetry distribution;
Brain injury
- From:
Chinese Journal of Radiological Medicine and Protection
2019;39(12):926-930
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare the dosimetrics of the plan target volume (PTV) and organs at risk (OARs) between two treatment planning approaches for patients with multiple brain metastases from non-small cell lung cancer on CyberKnife.
Methods:20 patients with multiple metastases from lung carcinoma were reviewed and analyzed, who had been treated by CyberKnife from December 2017 to December 2018. The CyberKnife stereotactic radiotherapy plans of the 20 cases were re-planed with single plan for multiple lesions and multiple plans per lesion. The dosimetry differences of PTV and OARs isodose disribution, conformity index (CI), total beam counts and total monitor units (MUs) were compared in the two types of plans.
Results:The two types of plans could satisfy over 95% PTV coverage of the prescription dose. The maximum and mean dose of normal brain adjacent to the PTV were reduced in multiple plan approach effectively. Moreover, the maximum and mean dose of OARs (brainstem) dropped by 1.62% and 5.57% (t=1.09, P<0.01) respectively. The number of treatment nodes and total MU declined by 4.63% (t=1.87, P<0.01)and 1.06% in multiple plan approach, which could significantly shorten the clinical treatment time. The differences in CI index between these two types of plans was of no statistical significance.
Conclusions:For patients with multiple brain metastases of similar diameter and volume from non-small cell lung cancer to be treated on CyberKnife, multiple plans per lesion could not only reduce dose to normal brain tissue and OARs, but also improve the treatment efficiency.
