Clinical outcomes of stereotactic body radiation therapy for T2N0M0 non-small cell lung cancer
10.3760/cma.j.issn.0254-5098.2019.12.005
- VernacularTitle: 30例T2N0M0期非小细胞肺癌立体定向放射治疗临床疗效分析
- Author:
Yaoyao ZHU
1
;
Shuangyan YANG
2
;
Wenyan YANG
2
;
Qingren LIN
3
;
Kainan SHAO
3
;
Qinghua XU
2
;
Hui LIU
2
;
Yaping XU
1
Author Information
1. First Clinical Medical School, Wenzhou Medical University, Wenzhou 325035, China
2. Department of Radiation Oncology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai 200433, China
3. Department of Radiation Oncology, Cancer Hospital of University of Chinese Academy of Sciences, Hangzhou 310022, China
- Publication Type:Journal Article
- Keywords:
Stereotactic body radiation therapy;
Non-small cell lung cancer;
Overall survival;
Progression-free survival;
Cause-specific survival
- From:
Chinese Journal of Radiological Medicine and Protection
2019;39(12):904-909
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical efficacy and adverse effects of stereotactic body radiotherapy (SBRT) in the treatment of T2N0M0 non-small cell lung cancer (NSCLC) patients.
Methods:By retrospectively analyzing the clinical data of 30 inoperable patients with stage T2N0M0 NSCLC treated by SBRT, the overall survival, progression-free survival, cancer-specific survival and adverse effects were determined.
Results:The median follow-up was 18.4 months. The 1-, 2-, and 3-year overall survival rates were 92.2%, 92.2% and 80.6%, respectively. The corresponding cause-specific survivals were 95.7%, 95.7% and 83.7%. The progression-free survivals were 70.2%, 54.1% and 40.6%. The local control rates were 100%, 94.4%, and 94.4%. The regional controls were 84.2%, 72.1%, and 54.1%; and distant controls were 84.6%, 72.4% and 64.3%, respectively. Twenty patients (66.7%) developed symptoms of grade 1 radiation-related toxicities: dyspnea, chest pain, fatigue, cough, esophagitis, or pneumonia. Among these, 5 patients suffered grade ≥2 radiation pneumonitis, and one patient experienced grade 4 radiation pneumonitis.
Conclusions:SBRT was efficient and safe for patients with inoperable T2N0M0 NSCLC, imposing tolerable toxicities.
