The comparative study between thromboelastography and conventional coagulation tests in ischemic cerebral vascular disease
10.3760/cma.j.issn.1671-0282.2019.12.006
- VernacularTitle: 血栓弹力图和传统凝血指标检测在缺血性脑血管病中的相关性研究
- Author:
Bin YAN
1
;
Tianxi HU
1
;
Xin LI
1
;
Shiqi LU
2
;
Qi WANG
3
;
Guangjian XU
4
;
Shuang PEI
4
;
Yiming ZHAO
3
;
Changgeng RUAN
3
Author Information
1. Department of Clinical Laboratory Medicine, Nanyang Central Hospital, Nanyang 473000, China
2. Department of Emergency, The First Affiliated Hospital of Soochow University, Suzhou 215006, China
3. Jiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, The First Affiliated Hospital of Soochow University, Suzhou 215006, China
4. Department of Neurology, Nanyang Central Hospital, Nanyang 473000, China
- Publication Type:Journal Article
- Keywords:
Thromboelastography;
Conventional coagulation tests;
Ischemic cerebral vascular disease;
Ischemic stroke;
Comparation
- From:
Chinese Journal of Emergency Medicine
2019;28(12):1490-1495
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the correlation and consistency between thromboelastography (TEG) and traditional coagulation tests (CCTs) in ischemic cerebral vascular disease (ICVD).
Methods:Totally 108 ICVD patients admitted to Nanyang Central Hospital from May 1 to October 31 2018 were enrolled. Patients’ TEG parameters (R value, K value, Angle value, MA value, CI value and G value) and CCTs parameters (PT, APTT, TT, and FIB) were collected and analyzed retrospectively. The Spearman correlation coefficient was used to explore the correlation between TEG and CCTs parameters, and Kappa (κ) to explore the consistency in determining the coagulation status of the patients. The ROC curve was used to analyze the predictive value of TEG parameters for abnormal results of CCTs, and the results of TEG and CCTs were comprehensively analyzed to evaluate the ability to predict the coagulation status of patients.
Results:(1) PLT was positively correlated with MA value and G value; PT and APTT were positively correlated with K value; TT was positively correlated with R value and K value; FIB was positively correlated with Angle value, MA value and G value. TT was negatively correlated with Angle value and CI value; FIB was negatively correlated with K value. (2) PT and MA values, PT and G values, FIB and MA values, FIB and G values were accordant in valuing the hypoxic state of ICVD patients. (3) PLT and Angle values, PLT and MA values, PLT and CI values, PLT and G values were accordant in assessing hypercoagulable status of ICVD patients; FIB and Angle values, FIB and MA values, FIB and CI value, and FIB and G value were consistent in evaluating the hypercoagulable state of ICVD patients. (4) For detecting TT>20 s, the AUC of K value and Angle value were 0.648, 0.651, respectively; For detecting FIB>4 g/L, the AUC of Angle value and MA value were 0.717 and 0.747, respectively; For detecting PLT>300×109/L, the AUC of MA value was 0.808 (all P<0.05).
Conclusions:There is weak correlation and consistency between TEG and CCTs parameters in ICVD patients. The TEG parameters have good predictive value in evaluating the abnormal results of CCTs, but cannot replace the CCTs. Combination of these two methods can better reflect the coagulation status of patients, so as to afford assistance.
