Progress in clinical research of varicella vaccines

VernacularTitle: 水痘疫苗的临床研究进展
Author: Lingxian QIU ¹ ; Xiaojuan YU ; Yingying SU ; Tong CHENG ; Ting WU
Author Information

1. National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, Xiamen University, Xiamen 361102, China
Publication Type:Review
Keywords: Varicella vaccine; Efficacy; Safety; Surveillance
From: Chinese Journal of Microbiology and Immunology 2019;39(12):951-957
CountryChina
Language:Chinese
Abstract: Varicella(chickenpox)is an acute infectious disease with high incidence in children. It is mainly transmitted through the airborne route and vaccination is the best measure for the prevention and control. Data from post-marketing studies show the effectiveness of varicella vaccines is 80%-85%, and two-dose regimen is significantly more effective than one-dose. After inclusion of varicella vaccines into the national immunization programme, there has been a clear decrease in varicella morbidity. Despite the lack of direct evidence, there remains the risk that varicella-zoster virus might latent in the dorsal route ganglia after vaccination. Therefore, more safe and effective novel varicella vaccines are under development. This paper reviewed the progress in varicella vaccine development and their long-term efficacy and safety.