Regulation of TNF-α on cell survival conditions and its relationship with ophthalmological disorders
10.3760/cma.j.issn.2095-0160.2019.12.016
- VernacularTitle: 肿瘤坏死因子-α对细胞生存状态的调控及其与眼科疾病的关系
- Author:
Wenna GAO
1
;
Liu YANG
Author Information
1. Department of Ophthalmology, Peking University First Hospital, Beijing 100034, China
- Publication Type:Review
- Keywords:
Tumor necrosis factor alpha;
Apoptosis;
Necroptosis;
Ophthalmology diseases;
Infliximab
- From:
Chinese Journal of Experimental Ophthalmology
2019;37(12):1029-1033
- CountryChina
- Language:Chinese
-
Abstract:
Tumor necrosis factor-α (TNF-α) is a key molecule of the inflammatory response, and plays a significant role in regulating cell survival and death.Many studies demonstrate that TNF-α may be implicated in the pathogenesis of various inflammatory conditions.Inhibiting the activity of TNF-α can dramatically improve the manifestations of many diseases.This review introduced the structural and functional characters of TNF-α and its receptors, and then summarized the regulating mechanisms TNF-α on cell survival、apoptosis and necroptosis.Besides, combining with the newly achievements of clinical and fundamental researches, this review analyzed the connections between TNF-α and common disorders in ophthalmology, such as the inflammation of retina and cornea, choroidal neovascularization, and summarized the clinical application and efficacy of infliximab, TNF-α monoclonal antibody.This review may provide references for the treatment of inflammatory diseases in ophthalmology and scientific researches in the future.
