Comparison of the low frequency fluctuation between AQP4 antibody positive and MOG antibody positive patients with optic neuritis
10.3760/cma.j.issn.2095-0160.2019.12.009
- VernacularTitle: AQP4抗体阳性与MOG抗体阳性视神经炎患者脑区低频振幅特征性变化比较
- Author:
Junqing WANG
1
;
Mingge LI
2
;
Huanfen ZHOU
1
;
Hui FENG
1
;
Quangang XU
1
;
Shihui WEI
1
Author Information
1. Department of Ophthalmology, PLA General Hospital, Beijing 100853, China
2. Department of Radiology, PLA General Hospital, Beijing 100853, China
- Publication Type:Clinical Trail
- Keywords:
Optic neuritis;
Resting-state functional magnetic resonance imaging;
Amplitude of low frequency fluctuation;
Neuromyelitis optica spectrum disorder;
Aquaporin 4 antibody;
Myelin oligodendrocyte glycoprotein antibody
- From:
Chinese Journal of Experimental Ophthalmology
2019;37(12):982-987
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare the changes of spontaneous brain activity in myelin oligodendrocyte glycoprotein antibody (MOG-Ab) positive and Aquaporin 4 antibody (AQP4-Ab) positive neuromyelitis optica spectrum disorder (NMOSD) by using resting-state functional magnetic resonance imaging (fMRI).
Methods:A case control study was designed.A total of 11 NMOSD patients with positive MOG-Ab and 21 NMOSD patients with positive AQP4-Ab were enrolled from October 2006 to May 2017 in PLA General Hospital.Thirty-four healthy controls closely matched in age, sex and education were recruited and underwent resting-state fMRI scans.The amplitude of low-frequency fluctuation (ALFF) was extracted to investigate the spontaneous brain activity.This study was approved by Ethics Committee of PLA General Hospital (S2019-111-01). All subjects enrolled signed informed consent.
Results:Two patients in the MOG-Ab positive group had seizure history, and no seizure history was observed in AQP4-Ab positive group and healthy control group.Compared with healthy control group, all patients in MOG-Ab positive group and AQP4-Ab positive group had significantly increased ALFF values of prefrontal gyrus.The ALFF values of bilateral anterior central gyrus and bilateral posterior central gyrus in AQP4-Ab positive group were 1.89±0.56 and 2.10±0.69, respectively, which were lower than 3.32±1.15 and 3.61±1.23 in MOG-Ab positive group, the differences were statistically significant (both at P<0.001, AlphaSim correction).
Conclusions:Resting-state fMRI could provide new evidence of possibly multi-focal disease mechanisms.Hyperactivity in prefrontal cortex, motor cortex and somatosensory cortex might reflect differences in pathological processes between MOG-Ab positive and AQP4-Ab positive NMOSD patients.
