Association of Vitamin D receptor gene polymorphisms with metabolic syndrome components in children and adolescents
10.3760/cma.j.issn.2095-428X.2019.12.019
- VernacularTitle: 儿童青少年维生素D受体基因多态性与代谢综合征组分的关系
- Author:
Di WANG
1
;
Fang XU
Author Information
1. Department of Pediatrics, Affiliated Hangzhou First People′s Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China
- Publication Type:Review
- Keywords:
Vitamin D receptor gene;
Obesity;
Metabolic syndrome;
Child
- From:
Chinese Journal of Applied Clinical Pediatrics
2019;34(12):954-957
- CountryChina
- Language:Chinese
-
Abstract:
The Vitamin D receptor (VDR) gene encodes the VDR protein, which is essential for the effective realization of the physiological function of vitamin D. Low vitamin D levels in children and adolescents increase the risk of obesity, insulin resistance, high blood pressure or dyslipidemia.However, the mechanisms are still unclear.It was found that VDR gene single nucleotide polymorphisms (SNP), especially BsmI, affect the level of vitamin D in children and adolescents.Some common SNP, such as BsmI, ApaI, TaqI, Cdx2, are associated with the occurrence of obesity and metabolic syndrome(MS). However, these associations are not significant in some studies, especially in obese group or with rare SNP.This review focuses on the relationship between VDR gene polymorphisms and MS components in children and adolescents, in order to provide direction for early diagnosis and intervention of MS and even the necessity and effectiveness of vitamin D replacement therapy.
