Clinical features of eye damage caused by glucocorticoid treatment in children with primary nephrotic syndrome
10.3760/cma.j.issn.2095-428X.2019.12.014
- VernacularTitle: 原发性肾病综合征患儿应用糖皮质激素治疗所致眼损害的临床特点
- Author:
Yuliu LI
1
;
Cuihua LIU
;
Shufeng ZHANG
;
Junfei LIU
Author Information
1. Department of Nephrology and Rheumatology, Children′s Hospital Affiliated to Zhengzhou University, Henan Children′s Hospital, Zhengzhou Children′s Hospital, Zhengzhou 450018, China
- Publication Type:Journal Article
- Keywords:
Primary nephrotic syndrome;
Glucocorticoid;
High intraocular pressure;
Cataract;
Child
- From:
Chinese Journal of Applied Clinical Pediatrics
2019;34(12):938-941
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the clinical characteristics of glucocorticoid induced eye damage in children with primary nephrotic syndrome.
Methods:The clinical data of steroid-induced high intraocular pressure or cataract in 49 children who were from Zhengzhou Children′s Hospital with primary nephrotic syndrome admitted from September 2016 to April 2018 were analyzed retrospectively in order to observe the relationship between relevant eye damage and clinical medication.
Results:There were 37 boys and 12 girls in the 49 cases, of which the average age of onset was (7.6±3.0) years old, and among them there were 22 cases with glucocorticoid high intraocular pressure, 19 cases with glucocorticoid cataract, 8 cases with glucocorticoid high intraocular pressure combined with cataract, but no glaucoma in 49 cases.The shortest time of using glucocorticoid was 15-3 240 days[(863.33±871.46) days]; the cumulative dose of glucocorticoid was (7 865±3 691.66) mg/m2, the left eye pressure was (26.68±5.95) mmHg(1 mmHg=0.133 kPa) and the right eye pressure was (27.71±5.82) mmHg.There was no significant correlation between glucocorticoid using time, cumulative dose and high intraocular pressure(r=-0.158, -0.264, -0.237, -0.361, all P>0.05). All the 19 patients with glucocorticoid cataract and 8 patients with glucocorticoid high intraocular pressure combined with cataract presented posterior capsular opacity, including 23 males and 4 females, and their time of using glucocorticoid was(1 296.67±903.35)days, who were followed up continuously.
Conclusions:Glucocorticoid-induced high intraocular pressure and cataract should be paid attention to by clinicians.Once high intraocular pressure or cataract occurs, the dosage of glucocorticoid should be gradually reduced or stopped, at the same time, ophthalmologic treatment should be actively performed to avoid serious eye diseases.
