Effect of the number of previous spontaneous abortions on the first in vitro fertilization cycle
10.3760/cma.j.issn.0529-567x.2019.12.003
- VernacularTitle: 既往自然流产次数对首次体外受精治疗结局的影响
- Author:
Yinfeng ZHANG
1
;
Haining LUO
1
;
Yaojia ZHANG
2
;
Rui SHI
2
;
Junfang MA
1
;
Yunshan ZHANG
1
Author Information
1. Reproductive Medicine Center, Tianjin Central Hospital of Gynecology Obstetrics, Tianjin Key Laboratory of Human Development and Reproductive Regulation, Tianjin 300052, China
2. Graduate School, Tianjin Medical University, Tianjin 300070, China
- Publication Type:Journal Article
- Keywords:
Abortion, spontaneous;
Fertilization in vitro;
Sperm injections, intracytoplasmic;
Pregnancy outcome
- From:
Chinese Journal of Obstetrics and Gynecology
2019;54(12):803-807
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of the number of previous spontaneous abortions on the first in vitro fertilization or intracytoplasmic sperm injection (IVF/ICSI) cycle.
Methods:A retrospective case-control study was conducted to analyze the clinical data of 1 279 patients who received IVF/ICSI treatment for the first time from July 2014 to July 2018 in Tianjin Central Hospital of Gynecology Obstetrics;they were divided into 0 time group (group A, n=924), 1 time group (group B, n=267) and 2 times group (group C, n=88) for comparison, according to the previous frequency of spontaneous abortions.
Results:There were no statistically significant differences in age, basal testosterone, estradiol, progesterone, prolactin and embryo quality in group A, B and C (all P>0.05). The biochemical pregnancy rate of group C (9.1%) was higher than those of the other two groups (4.1% and 4.1%; all P>0.05). The clinical pregnancy rate of group A (42.5%) [>group B (40.4%) and >group C (35.2%)] was not statistically significant(P>0.05).Early abortion rate in group A (8.9%) wasP<0.05).The live birth rate of group C (21.6%) was significantly lower than that of group A (35.5%; P<0.05), but the difference between group C and group B (30.7%) was not statistically significant (P>0.05).
Conclusions:Women with a history of one- or two-time spontaneous abortion have no obvious effect on embryo quality, and have a negative impact of clinical pregnancy rate, early abortion rate, live birth rate in the first IVF/ICSI cycle; especially for patients with a history of two times spontaneous abortion, early abortion rate has a significant increase, live birth rate decreases significantly, suggesting that patients with a history of two times of spontaneous abortion should find the causes of miscarriage according to the process of recurrent spontaneous miscarriage and receive treatment if necessary before subsequent pregnancy.
