Chromosome abnormality rate and related factors of spontaneous abortion in early pregnancy
10.3760/cma.j.issn.0529-567x.2019.12.002
- VernacularTitle: 妊娠早期自然流产组织染色体异常情况及其相关因素分析
- Author:
Jiandong SHEN
1
;
Fangxi SUN
;
Dianyun QU
;
Jiazi XIE
;
Li GAO
;
Qian QIU
;
Chao GAO
;
Wei WU
;
Chunxiang WU
;
Daowu WANG
;
Feiyang DIAO
;
Jiayin LIU
Author Information
1. The Center of Reproductive Medicine, the First Affiliated Hospital of Nanjing Medical University, State Key Laboratory of Reproductive Medicine, Nanjing 210029, China
- Publication Type:Journal Article
- Keywords:
Abortion, spontaneous;
Chromosome aberrations;
Pregnancy trimester, first;
High-throughput nucleotide sequencing;
Fertilization in vitro;
Embryo transfer
- From:
Chinese Journal of Obstetrics and Gynecology
2019;54(12):797-802
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate chromosome abnormality rate and related factors of spontaneous abortion in early pregnancy.
Methods:A total of 831 tissue samples of spontaneous abortion in early pregnancy were collected from June 2015 to August 2018 in the First Affiliated Hospital of Nanjing Medical University. Chromosomal copy number was analyzed by next generation sequencing (NGS). The relationships between chromosome abnormality and maternal age, in vitro fertilization-embryo transfer (IVF-ET) pregnancy, number of previous spontaneous abortions, history of live birth were analyzed by statistical methods.
Results:Among 831 tissue samples of spontaneous abortion in early pregnancy, 461 (55.5%, 461/831) were found to have chromosome abnormalities. Maternal age (OR=1.107, 95%CI: 1.070- 1.145) and history of live birth (OR=1.909, 95%CI: 1.182-3.083) were the positive correlative factors of chromosome abnormality. Times of previous spontaneous abortion (OR=0.807, 95%CI: 0.702-0.928) and IVF-ET pregnancy (OR=0.554, 95%CI: 0.404-0.760) were the negative correlative factors of chromosome abnormality.
Conclusions:Chromosome abnormality is an important cause of spontaneous abortion in early pregnancy. The rate of chromosome abnormality increases with the increase of maternal age and the history of live birth, and decreases with the increase of number of previous spontaneous abortion and IVF-ET pregnancy.
