Mitochondrial quality control system as a therapeutic target for treating heart failure
10.3760/cma.j.issn.2095-4255.2019.12.021
- VernacularTitle: 线粒体质量控制系统作为心力衰竭潜在治疗靶点的研究进展
- Author:
Junfan LI
1
;
Shuqiu SUN
;
Yingxue WANG
;
Kunyu ZHANG
Author Information
1. Institute of Keshan Disease, Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin 150081, China
- Publication Type:Review
- Keywords:
Mitochondria;
Quality control;
Heart failure
- From:
Chinese Journal of Endemiology
2019;38(12):1028-1032
- CountryChina
- Language:Chinese
-
Abstract:
The mitochondrial quality control system maintains mitochondrial homeostasis mainly through protein degradation, vesicle transport, and mitophagy. Mitochondrial biosynthesis, dynamics, and calcium ion play key regulative roles in mitochondrial quality control. Under normal conditions, the mitochondrial quality control system can work well. In recent years, studies have found that mitochondrial dysfunction is closely associated with the occurrence of heart failure. In order to understand mitochondrial function, this paper reviews mitochondrial quality control methods, regulatory factors and their potential therapeutic applications in heart failure.
