Advances in research on the pathogenesis of osteoarticular brucellosis
10.3760/cma.j.issn.2095-4255.2019.12.019
- VernacularTitle: 布鲁菌骨关节病发病机制的研究进展
- Author:
Jiangbi LI
1
;
Yongjie WANG
1
;
Jun LIU
2
;
Shaokun ZHANG
1
Author Information
1. Department of Spinal Surgery, the First Hospital of Jilin University, Changchun 130021, China
2. Institute of Military Veterinary Medicine, Academy of Military Medical Sciences, Key Laboratory of Jinlin Province for Zoonosis Prevention and Control, Changchun 130022, China
- Publication Type:Review
- Keywords:
Brucellosis;
Bone and bones;
Joints;
Osteoblast;
Osteoclast
- From:
Chinese Journal of Endemiology
2019;38(12):1019-1022
- CountryChina
- Language:Chinese
-
Abstract:
Brucellosis is a common bacterial zoonotic disease that affects a variety of organs and tissues and causes a variety of clinical manifestations. Bone and joint are the most frequently involved parts, among which sacroiliac arthritis, spondylitis and peripheral arthritis are the most common osteoarticular disease. Brucella induces bone damage by affecting various cells of the skeletal system and the immune system, Brucella increases the expression of nuclear factor kappa B receptor activating factor ligand (RANKL), tumor necrosis factor (TNF)-α and interleukin (IL)-17 in osteoclasts and osteocytes, enhances the activity of osteoclasts. Brucella can proliferate in osteoblasts and osteocytes, induce apoptosis of osteoblasts and osteocytes, and inhibit the deposition of mineral and organic matrix in osteoblasts. After Brucella infection, inflammatory cells such as monocyte macrophages, neutrophils, T cells and B cells also participate in the inflammatory response, these inflammatory cells and bone system secrete more pro-inflammatory cytokines, chemokines and matrix metalloproteinases (MMPs), which enhance the inflammatory response and promote the degradation of extracellular matrix. Finally, the bone homeostasis is broken and the bone injury is aggravated. With the development of research on the molecular mechanism of Brucella osteoarthropathy, more and more people will understand the pathogenesis of chronic osteoarthropathy caused by Brucella.
