Research progress of 12-HETE in the inflammation and oxidative stress
10.3760/cma.j.issn.2095-4352.2019.12.027
- VernacularTitle: 12 -羟基二十碳四烯酸在炎症及氧化应激中的研究进展
- Author:
Qian CHENG
1
;
Lixing TIAN
2
;
Huaping LIANG
2
;
Yan LUO
1
Author Information
1. Department of Clinical Laboratory, First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
2. First Department, State Key Laboratory of Trauma, Burns and Combined injury, Research Institute of Surgery, Army Specialized Medical Center of Army Medical University, Chongqing 400042, China
- Publication Type:Review
- Keywords:
12-HETE;
Inflammation;
Oxidative stress;
Regulatory strategy
- From:
Chinese Critical Care Medicine
2019;31(12):1555-1558
- CountryChina
- Language:Chinese
-
Abstract:
12-HETE is a metabolite of arachidonic acid (AA). AA is normally present in membrane phospholipids. The exposure to different stimuli can trigger the release of AA through the activity of phospholipase A2 (PLA2) by cells. An important metabolic pathway which utilizes AA as its substrate is 12-Lipoxygenase (12-LOX), resulting in the formation of 12-HETE. 12-HETE plays an important role in many diseases such as cancer, diabetes, hypertension, and participates in the pathogenesis of inflammation and oxidative stress and other pathological processes.Current research shows that it participates in metamorphism and exudation in the process of inflammation. This review is aimed at summarizing its role in inflammation and oxidative stress, with improved understanding of 12-HETE.
