Association of CHRNA4 gene polymorphisms with response to antidepressant among ethnic Han Chinese
10.3760/cma.j.issn.1003-9406.2019.12.020
- VernacularTitle: CHRNA4基因多态性与重度抑郁发作治疗反应的关系研究
- Author:
Jianying YU
1
;
Zaiquan DONG
1
;
Tao YU
2
;
Xirong LI
3
;
Xueli SUN
1
Author Information
1. Psychological Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China
2. Bio-X Institute, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders of the Ministry of Education, Shanghai Jiao Tong University, Shanghai 200030, China
3. Shandong Mental Health Center, Jinan, Shandong 250014, China
- Publication Type:Clinical Trail
- Keywords:
Major depressive disorder;
CHRNA4 gene;
Selective serotonin re-uptake inhibitor
- From:
Chinese Journal of Medical Genetics
2019;36(12):1230-1234
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To assess the association of single nucleotide polymorphisms (SNPs) CHRNA4 gene with response to selective serotonin re-uptake inhibitors (SSRIs) for the treatment of major depressive disorder (MDD).
Methods:For 304 patients receiving drug treatment for major depression, 2 SNPs, namely rs4522666 and rs4603829, of the CHRNA4 gene were determined by matrix-assisted laser desorption/ionization time of flight (MALDI-TOF) mass spectrometry. HAMD-17 was adopted as the primary rating tool to evaluate the severity of depression on the baseline and at the end of 1st, 2nd, 4th and 6th weeks treatment.
Results:The frequency of GG genotype/G allele for rs4522666 differed significantly from that of TT and GT genotypes/T allele between responders and non-responders (P =0.015 and P=0.006, respectively). No significant difference was found in genotypic and allelic frequencies of rs4603829 between the two groups (P > 0.05).
Conclusion:SNPs of the CHRNA4 gene may play an important role in the response to antidepressant drugs among ethnic Han Chinese with MDD.
