Advances in research into the effect of chondroitin sulfate proteoglycan on orderly regeneration of peripheral nerves
10.3760/cma.j.issn.1671-7600.2019.12.017
- VernacularTitle: 硫酸软骨素蛋白多糖对周围神经有序再生作用的研究进展
- Author:
Fulin HE
1
;
Dong YANG
2
;
Qingtang ZHU
1
Author Information
1. Department of Microsurgery and Orthopedic Trauma, The First Affiliated Hospital to Sun Yat-sen University, Center for Peripheral Nerve Tissue Engineering and Technology Research, Guangdong Province Engineering Laboratory for Soft Tissue Biofabrication, Guangzhou 510080, China
2. Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Centre, Guangzhou 510060, China
- Publication Type:Review
- Keywords:
Proteochondroitin sulfates;
Peripheral nerves;
Nerve regeneration
- From:
Chinese Journal of Orthopaedic Trauma
2019;21(12):1097-1100
- CountryChina
- Language:Chinese
-
Abstract:
It is difficult for peripheral nerves to achieve effective and orderly regeneration after injury for there are always mismatched, curly and disorderly newborn axons. Chondroitin sulfate proteoglycan (CSPGs), a kind of widespread extracellular matrix generally considered to inhibit peripheral nerve regeneration, may play an important role in promoting orderly regeneration of axons depending on its classification, physiological characteristics and spatial and temporal distribution as well. Complementing traditional modes of regenerating axons, its flexible applications may benefit biomimetic construction of peripheral nerve grafts that purely increase the number of axons and thus promote orderly and effective regeneration after peripheral nerve lesions.
