Iron accumulation induces osteoporosis by disrupting Wnt signaling pathway
10.3760/cma.j.issn.1000-6699.2019.12.012
- VernacularTitle: 铁蓄积通过干扰Wnt信号通路导致骨质疏松
- Author:
Guangfei LI
1
;
Hui ZHANG
;
Aifei WANG
;
Zihou CAO
;
Yan GAO
;
Youjia XU
Author Information
1. Department of Orthopaedics, the Second Affiliated Hospital of Soochow University, Suzhou 215004, China
- Publication Type:Journal Article
- Keywords:
Iron accumulation;
Osteoporosis;
Wnt signaling pathway
- From:
Chinese Journal of Endocrinology and Metabolism
2019;35(12):1061-1064
- CountryChina
- Language:Chinese
-
Abstract:
The specimens of femur from wild-type mice(WT) of 6 months and Hepcidin-knockout(KO) mice of 6 months(iron accumulation model) were obtained for Micro-CT examination. Western blot and co-immunoprecipitation were used to detect the changes of related parameters in Wnt signaling pathway. Compared with wild-type mice, the bone mass in Hepcidin-KO mice was significantly decreased, the binding of β-catenin to FOXO3a increased, and binding of β-catenin to TCF4/TCF7L2 decreased in bone tissue, without significant changes in the expression of β-catenin, TCF4/TCF7L2, and FOXO3a. These results suggest that iron accumulation may affect bone formation through interfering with canonical Wnt/β-catenin signaling pathway, finally leading to osteoporosis.
