Observation of the therapeutic effect of different time intake on patients with acute oral organophosphorus pesticide poisoning
10.3760/cma.j.issn.1672-7088.2020.04.002
- VernacularTitle: 不同时间进食对急性口服有机磷农药中毒患者治疗效果的观察
- Author:
Weihong CONG
1
;
Wanhua YAN
1
;
Hailing DU
2
;
Xuqiang DU
2
;
Xiang WANG
2
;
Liqiang WU
2
;
Yuxia LIU
2
Author Information
1. Binzhou Medical University, Binzhou 256600, China
2. Department of Emergency, the Affiliated Hospital of Binzhou Medical University, Binzhou 256600, China
- Publication Type:Journal Article
- Keywords:
Oral;
Poisoning;
Organophosphorus pesticides;
Early feeding;
The meal time
- From:
Chinese Journal of Practical Nursing
2020;36(4):247-251
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the best time of early feeding in patients with acute oral organophosphorus pesticide poisoning.
Methods:A prospective study was conducted on 123 patients with acute oral organophosphorus poisoning admitted from January 2018 to May 2019 in Department of Emergency, the Affiliated Hospital of Binzhou Medical University. The patients were divided into four groups, A(<6 h), B(≥6 h-<12 h), C(≥12 h-<24 h) and D(≥24 h), according to the time of poisoning at the time of admission. All the patients in the four groups were fed immediately upon admission with the same method. The cholinesterase activity at 24, 48, 72, 120 h after poisoning, the incidence of rebound after poisoning, the disappearance time of clinical poisoning symptoms were compared among the four groups.
Results:Compared with the other three groups, group A had a statistically significant difference in the cholinesterase activity at 24, 48, 72, 120 h after poisoning (H value was 9.466-24.933, P<0.05 or 0.01). There was no significant difference between the two groups in B, C, D group (P>0.05). The incidence of rebound after poisoning in A, B, C, D group was 3.448%(1/30), 7.407%(2/29), 6.452%(2/33), 6.897%(2/31), respectively, with no statistically significant difference (χ2 value was 0.431, P>0.05). Compared with the four groups, the disappearance time of clinical poisoning symptoms in group A was shorter than that in the other three groups, and the difference was statistically significant (H value was18.199, P<0.05).
Conclusions:The earlier the patients ate, the faster the recovery of cholinesterase activity, the earlier the improvement of poisoning symptoms, and the incidence of gastrointestinal reaction and rebound after poisoning is not increased.The best time for early feeding is less than 6 h after poisoning.
