Curative effect of compound carraghenates cream combined with vitamin B6 in the treatment of hand-foot syndrome caused by capecitabine
10.3760/cma.j.issn.1008-6706.2020.03.011
- VernacularTitle: 复方角菜酸酯乳膏联合维生素B6片治疗卡培他滨所致手足综合征的疗效观察
- Author:
Long LI
1
;
Feng YING
1
;
Xiaozhou YING
2
Author Information
1. Department of Anorectal Diseases, the First People's Hospital of Yongkang, Yongkang, Zhejiang 321300, China
2. Department of Traumatology, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China
- Publication Type:Journal Article
- Keywords:
Capecitabine;
Carraghenates;
Vitamin B6;
Hand-foot Syndrome
- From:
Chinese Journal of Primary Medicine and Pharmacy
2020;27(3):301-305
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the curative effect of compound carraghenates cream(Titanoreine) combined with vitamin B6 in the treatment of hand-foot syndrome caused by capecitabine(Xeloda).
Methods:From December 2015 to December 2017, 97 cases of middle and advanced colorectal cancer in the First People's Hospital of Yongkang were selected.All patients were treated by chemotherapy regimens of capecitabine as priority after operation, but later hand-foot syndrome appeared and they were randomly divided into treatment group (48 cases) and control group (49 cases) according to the digital table.In control group, only vitamin B6 30 mg was taken orally, three times daily; while in treatment group, vitamin B6(30 mg) combined with compound carraghenate cream (1g) were taken orally, three times daily after hand-foot syndrome occurred.The improvement, total efficiency, pain score during the treatment process (the first, fifth, ninth day after treatment), adverse reactions were observed before and after treatment in two groups.
Results:After treatment, the hand-foot syndrome in the treatment group and the control group was improved, the difference was statistically significant (treatment group: Z=6.477, P=0.000; control group: Z=4.700, P=0.000). The total effective rate of the treatment group was 87.5%(42/48), which was significantly higher than 65.3%(32/49) of the control group (χ2=6.603, P=0.010). The pain score on the ist day after treatment had no statistically significant differences between the two group[treatment group: (2.88±1.82)points, control group: (3.14±1.74)points, t=0.741, P=0.461] The pain scores on 5th and 9th day after treatment in the treatment group were (2.29±1.52)points, (1.23±1.80)points, respectively, which were lower than those in the control group [(2.94±1.38)points, (2.14±1.90)points](t=2.200, 2.430, P=0.030, 0.017). There were no statistically significant differences between the two groups in general conditions and the incidence of adverse reactions after drugs uses(all P<0.05).
Conclusion:Compound carraghenate cream combined with vitamin B6 has significant effect in the treatment of hand-foot syndrome caused by capecitabine, which can improve hand-foot syndrome better and help tumor patients to finish the chemotherapy successfully.
