The clinical significance of serum autoantibodies and HLA-B27 molecule testing in Uygur patients with human immunodeficiency virus infection
10.3760/cma.j.issn.0578-1426.2020.03.005
- VernacularTitle: 新疆维吾尔自治区库车县维吾尔族人类免疫缺陷病毒感染者血清自身抗体及人类白细胞抗原-B27检测的临床意义初探
- Author:
Xiaomei CHEN
1
;
Cainan LUO
1
;
Lijun WU
1
;
Yamei SHI
1
;
Xue WU
1
;
Xinyan MENG
1
;
Xin LEI
1
;
Yong LIU
2
;
Yimiti REYIMUJIANG
2
;
Kare GULIMIRE
1
;
Tingyu WANG
1
;
Feifei XIA
1
Author Information
1. Department of Rheumatology and Immunology, People′s Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830001, China
2. Department of Infectious Disease, Kuche Infectious Disease Hospital, Xinjiang Uygur Autonomous Region Kuche 842000, China
- Publication Type:Journal Article
- Keywords:
HIV infected;
Rheumatic diseases;
Autoantibodies;
HLA-B27 antigen
- From:
Chinese Journal of Internal Medicine
2020;59(3):195-199
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the clinical value of serum autoantibodies and human leukocyte antigen (HLA-B27) molecular testing in Uygur patients with human immunodeficiency virus (HIV) infection.
Method:A total of 727 HIV-infected Uygur patients who visited Kuche infectious diseases hospital during May 2016 to March 2017 were include in this study. The other 390 healthy people were enrolled as controls. Serum antinuclear antibodies (ANA), anti-cyclic citrullinated peptide (CCP) antibody, anti-extractable nuclear antigen (ENAs) antibody and HLA-B27 molecule were tested.
Result:Among 727 HIV-infected Uygur patients, 317 were males and 410 were females with mean age (35.52±13.44) years old. The mean duration of disease was (6.34±3.05) years. There were 697 (95.87%) patients receiving highly active antiretroviral therapy (HAART) with mean duration of treatment (5.52±3.47) years. The mean CD4+T cell count was (520±271) cells/μl in 202 HIV-infected patients, and mean virus load was (108 139±20 498) copies/ml in 20 HIV-infected patients. Rheumatic manifestations were recorded in 238 (32.74%) HIV-infected Uygur patients, mainly with dry mouth and dry eye (15.41%) , alopecia (9.90%) , arthralgia (8.94%) , ect. Compared with the health controls, positive ANA was more common in HIV infected Uygur patients (33.43% vs. 17.43%, P<0.001) with low titers (ANA titer:1∶100) . HIV-infected Uygur patients had higher positive anti-u1-RNP antibodies positive rate (1.10%), but lower anti-SSA antibodies positive rate (0.14%) and anti-CCP antibodies positive rate (0.28%). Patients with positive ANA in HAART group were significantly less than that in non-treatment group (32.71% vs. 50.00%, P=0.049). There were no correlations between ANA and duration of HAART, CD4+T cell counts and virus load (r values 0.061, 0.047, 0.121, respectively. P>0.05). Only one female patient was HLA-B27 positive (0.14%), which was significantly lower than that in healthy controls (3.08%) (P<0.001). Also, only one patient was diagnosed with rheumatoid arthritis (RA).
Conclusion:Autoimmune manifestations are common in HIV-infected Uygur patients. Several autoantibodies are positive, but the coincidence of rheumatic diseases is rare. It′s noted that patients with autoimmune manifestations should be considered as a differential diagnosis of HIV infection.
