Study on the inclusion technic of hydroxypropyl-β-cyclodextrin in tea tree oil and evaluation of its included compounds
10.3760/cma.j.issn.1673-4246.2020.02.012
- VernacularTitle: 茶树油羟丙基-β-环糊精包合工艺研究及其包合物评价
- Author:
Han ZHANG
1
;
Bo ZHANG
2
;
Ping YAN
1
;
Boru MA
1
;
Wenxia HAN
1
;
Weize LI
1
;
Xifeng ZHAI
1
Author Information
1. Department of Pharmacy Xi'an Medical University, Xi'an 710021, China
2. Shaanxi Bicong Pharmaceutical Group Holding Company Limited, Xi'an 710021, China
- Publication Type:Journal Article
- Keywords:
Tea tree oil;
Hydroxypropyl-beta-cyclodextrin;
Inclusion complex;
Drug stability;
Orthogonal test;
Dosage forms improving
- From:
International Journal of Traditional Chinese Medicine
2020;42(2):157-162
- CountryChina
- Language:Chinese
-
Abstract:
Objective:This study takes hydroxypropyl-β-cyclodextrin (HP-β-CD) as the inclusion materials to optimize the preparation technic of tea tree oil (TTO) and evaluate its pharmaceutical performance.
Methods:Take the production rate of HP-β-CD tea tree oil inclusion and entrapment rate as the evaluation index, taking the orthogonal test method to optimize the production technic of tea tree oil (HP-β-CD inclusion and using infrared (IR), differential thermal scanning (DSC) method to characterize the inclusion compound to analyze the stability of TTO-HP-β-CD.
Results:The best technic to produce HP-β-CD tea tree oil is as follow: the ratio of TTO and HP-β-CD should be equal to 1/10, at 40 ℃, within 1 h. The average drug loading shoud be 9.25% ± 3.25%. The IR, DSC characterization results showed that the characteristic peak of tea tree oil disappeared after the microspheres, which indicated the HP-β-CD encapsulated the tea tree oil with good compatibility. In 80 ℃ water bath, the TTO-HP-β-CD was stable with the retention rate 40% after 8 h, the retention rate was 4.32 times than that of the unwrapped tea tree oil.
Conclusions:The HP-β-CD tea tree oil obviously has higher rate of inclusion and stability. Therefore, it’s worth to promoting and being used in the pharmacy preparations and cosmetics field.
