Study on the mechanism of two related Chinese herbs Danggui-Baishao in treating cardiovascular diseases based on network pharmacology
10.3760/cma.j.issn.1673-4246.2020.02.011
- VernacularTitle: 基于网络药理学的当归-白芍药对治疗心血管疾病作用机制研究
- Author:
Xiaoquan JIANG
1
;
Yang LIU
1
;
Xueyan LI
1
;
Xing HAN
1
;
Bin MAO
2
Author Information
1. School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, China
2. Department of Cardiac Surgery, Capital Medical College Affiliated Beijing Anzhen Hospital, Beijing 100029, China
- Publication Type:Journal Article
- Keywords:
Angelica sinensis;
Paeoniae radix alba;
Couplet medicines;
Cardiovascular diseases;
Network pharmacology
- From:
International Journal of Traditional Chinese Medicine
2020;42(2):151-156
- CountryChina
- Language:Chinese
-
Abstract:
Objective:By adopting network pharmacology to study the mechanism of the two classical Chinese herbs Danggui-Baishao in treating cardiovascular diseases.
Methods:By searching from TCMSP and related literature, together with the databases of TCMSP, SWISS and STITCH, potential active compounds of Danggui-Baishao were collected, while the targets for cardiovascular diseases were obtained from TTD, OMIM and DrugBank databases. Then the PPI network was screened for the major targets. The KEGG Pathway annotation analyses of major targets were performed by using the DAVID database. The ingredient-major target-key pathway network was constructed by Cytoscape.
Results:There were 17 compounds and 54 major targets in the ingredient-target-pathway network, as well as 10 key pathways, including inflammation-related pathway (TNF signaling pathway), pathways related to cardiovascular system (such as PI3K-Akt signaling pathway, FoxO signaling pathway, VEGF signaling pathway, Rap1 signaling pathway), prolactin signaling pathway and estrogen signaling pathway.
Conclusions:The study verified the characteristics of multi-components, multi-targets and integral regulation for Danggui-Baishao with the application of network pharmacology. It predicted that Dangui-Baishao couldtreat cardiovascular diseases mainly by regulating angiogenesis, inflammatory response and apoptosis.
