Effect of Qishen-Xiaodian Decoction combined with laser acupoint irradiation on recurrence oxidative stress and renal function oin children with henoch schonlein purpura
10.3760/cma.j.issn.1673-4246.2020.02.006
- VernacularTitle: 芪参消癜汤联合激光穴位照射对复发性过敏性紫癜患儿氧化应激状态及肾功能的影响
- Author:
Xin CHANG
1
;
Zhibin DAI
2
;
Guixian LI
2
;
Lifang WANG
1
;
Yingjie FENG
1
;
Yunliang ZHOU
1
;
Genhui WANG
3
Author Information
1. Department of Dermatological, Hospital of Xinle City of Hebei Province, Xinle 050700, China
2. Department of Clinical Laboratory, Xinle City Central Hospital of Hebei Province, Xinle 050700, China
3. Department of Dermatological, Tradiontral Chinese Medicine Hospital of Hebei Province, Shijiazhuang 050011, China
- Publication Type:Clinical Trail
- Keywords:
Purpura, schoenlein-henoch;
Recurrence;
Qishen-Xiaodian Decoction;
Lasers, semiconductor;
Oxidative stress;
Kidney function tests
- From:
International Journal of Traditional Chinese Medicine
2020;42(2):124-128
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the effect of Qishen-Xiaodian Decoction combined with laser acupoint irradiation on oxidative stress and renal function on children with recurrent henoch schonlein purpura (HSP).
Methods:A total of 120 children with recurrent HSP in the dermatology department clinic of Hospital of Xinle City from January 2015 to November 2017 were divided into two groups according to the random number table method, with 60 cases in each group. The control group took loratadine, Troxerutin and vitamin C orally, while the treatment group took Chinese medicine combined with laser acupoint irradiation based onthe control group. Drugs were taken orally for 4 weeks, laser acupoint irradiation treatment for 2 weeks. The level of glutathione peroxidase (GSH-Px) in plasma was detected by ELISA, the levels of MDA and SOD in plasma were detected by thiobarbituric acid colorimetry and hydroxylamine method, the level of IgG, micro albumin (Alb), β2-microglobulin (β2-MG) in urine were detected by radioimmunoassay, and the clinical effect was evaluated. The recurrence was recorded.
Results:After treatment, the plasma GSH-Px (90.45 ± 15.36 μmol/L vs. 81.62 ± 13.68 μmol/L, t=3.318), SOD (99.64 ± 18.66 IU/ml vs. 84.21 ± 16.73 IU/ml, t=4.769) in the treatment group were significantly higher than the control group (P<0.01); the MDA (5.58 ± 1.31 μmol/L vs. 4.37 ± 1.36 μmol/L, t=4.964) was significantly lower than the control group (P<0.01); the ratio of urine IgG (3.48 ± 0.95 mg/L vs. 6.56 ± 1.47 mg/L, t=13.630), Alb (7.80 ± 2.94 mg/L vs. 12.73 ± 4.26 mg/L, t=7.378), β2-MG (4.02 ± 1.61 mg/L vs. 6.95 ± 2.10 mg/L, t=8.577) were significantly lower than those of the control group (P<0.01). The total effective rate was 95.0% (57/60) in the treatment group and 80.0% (48/60) in the control group. There was statistically significant difference between two groups (χ2=6.171, P=0.013). Follow-up of 6 and 12 months, the recurrence rate of the treatment group were significantly lower than that of the control group (χ2 value were 4.931, 4.574, P<0.05).
Conclusions:Qishen-Xiaodian Decoction combined with laser acupoint irradiation can improve the oxidative stress of children with recurrent HSP, protect the renal function, improve the clinical efficacy and reduce the recurrence rate.
