The Assessment of Midazolam Effect as Premedication by Bispectral Index System.
10.4097/kjae.2000.38.6.947
- Author:
Seong Wan BAIK
1
;
Ji Heum RYU
;
Kyoo Sub CHUNG
;
Inn Se KIM
;
Hae Kyu KIM
;
Jae Young KWON
Author Information
1. Department of Anesthesiology, College of Medicine, Pusan National University, Pusan, Korea.
- Publication Type:Original Article
- Keywords:
Monitoring: bispectral index;
Premedication: midazolam
- MeSH:
Anesthesia, General;
Blood Pressure;
Electroencephalography;
Fentanyl;
Glycopyrrolate;
Heart Rate;
Hemodynamics;
Humans;
Intubation;
Midazolam*;
Premedication*;
Propofol;
Succinylcholine
- From:Korean Journal of Anesthesiology
2000;38(6):947-953
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Midazolam is often used as an anxiolytic premedication before surgery, but it is difficult and complex to assess its effect. This study evaluated the bispectral index as an objective indicator of midazolam premedication and the relation of cardiovascular response to anesthetic induction. METHODS: Forty patients (aged 20 to 60 and in ASA class I or II) to undergo simple elective surgery under general anesthesia entered the study. The patients were divided into the midazolam group (n = 20) that received midazolam (0.08 mg/kg IM) and glycopyrrolate (0.2 mg IM) premedication, and the control group (n = 20) that received glycopyrrolate (0.2 mg IM) only. Then, anesthetic induction (fentanyl 1 microgram/kg, propofol 2 mg/kg, succinylcholine 1 mg/kg) was done. The bispectral index of the electroencephalogram, blood pressure, and heart rate were measured under unanesthetized conditions, after fentanyl, propofol injection, and intubation. RESULTS: The bispectral index was significantly lower in the midazolam group as compared with the control group before anesthetic induction, after fentanyl injection, and intubation. Blood pressure was not significantly different in the two groups. Heart rate was significantly lower in the midazolam group compared with the control group before anesthetic induction and after fentanyl injection. CONCLUSIONS: Midazolam-premedicated patients appear to maintain stable hemodynamics during anesthetic induction and intubation. The bispectral index can be objectively used in midazolam-premedicated patients when evaluating the degree of sedation. (Korean J Anesthesiol 2000; 38: 947~953)
