Clinical effect of Astragalus injection combined with meropenem in the treatment of severe infection patients and its influence on T lymphocyte subsets and inflammatory factors in peripheral blood
10.3760/cma.j.issn.1008-6706.2020.02.018
- VernacularTitle: 黄芪注射液联合美罗培南治疗重症感染的效果观察及对血T淋巴细胞亚群和炎性因子影响
- Author:
Weiguo YING
1
;
Qinglin GAO
1
;
Zhuo LI
1
Author Information
1. Department of Critical Care Medicine, Yiwu Fuyuan Private Hospital, Yiwu, Zhejiang 322000, China
- Publication Type:Journal Article
- Keywords:
Bacterial infections;
T-lymphocyte subsets;
Calcitonin;
Tumor necrosis factor-alpha;
C-reactive protein;
Astragalus injection;
Meropenem
- From:
Chinese Journal of Primary Medicine and Pharmacy
2020;27(2):205-208
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical effect of Astragalus injection combined with meropenem in the treatment of severe infection patients and its influence on T lymphocyte subsets and inflammatory factors in peripheral blood.
Methods:From January 2016 to December 2018, 80 patients with severe infections in Yiwu Fuyuan Private Hospital were selected and divided into observation group (n=40) and control group (n=40) according to single blind random table method.The observation group was treated with Astragalus injection combined with meropenem, while the control group was treated with meropenem.Both two groups were treated for 10 days.The therapeutic effects, changes of body temperature, heart rate and respiratory rate, changes of T lymphocyte subsets and inflammatory factors in peripheral blood, and negative time of bacterial culture before and after treatment were compared between the two groups.
Results:The total effective rate of the observation group (92.50%) was higher than that of the control group (70.00%) (χ2=6.646, P<0.05). After treatment, the levels of CD3+ [(62.38±4.51)%], CD4+ [(40.63±2.15)%] and CD4+ /CD8+ (1.63±0.18) in the observation group were higher than those in the control group [(57.27±3.19)%, (35.47±1.93)% and (1.30±0.21)] (t=5.850, 11.296, 7.546, all P<0.05). After treatment, the levels of CRP [(28.79±8.74)mg/L], PCT [(0.56±0.12)g/L] and TNF-α [(157.93±20.47)pg/mL] in the observation group were lower than those in the control group [(43.71±12.67)mg/L, (1.10±0.23)g/L and (247.16±34.64)pg/mL] (t=13.640, 13.165, 14.026, all P<0.05). The negative turning time of bacterial culture in the observation group [(4.36±1.29)d] was shorter than that in the control group [(7.43±1.57)d] (t=9.493, P<0.05).
Conclusion:Astragalus membranaceus injection combined with meropenem has significant clinical effect in the treatment of patients with severe infections.It can improve cellular immune function and reduce inflammatory reaction, which is worthy of clinical reference.
