Serum low-density lipoprotein receptor-related protein 6 level and its clinical significance in patients with acute myocardial infarction
10.3760/cma.j.issn.1673-4904.2020.02.013
- VernacularTitle: 急性心肌梗死患者血清低密度脂蛋白受体相关蛋白6水平及临床意义
- Author:
Dongjian CHAI
1
;
Jing ZHENG
;
Zhenyan GAO
;
Xiaoming TU
;
Geyi ZHU
Author Information
1. Department of Cardiology, Quzhou People′s Hospital of Zhejiang, Zhejiang Quzhou 324000, China
- Publication Type:Journal Article
- Keywords:
Coronary artery disease;
Lipoprotein receptor related protein 6;
Left ventricular ejection fraction;
B-type brain natriuretic peptide;
Troponin
- From:
Chinese Journal of Postgraduates of Medicine
2020;43(2):154-157
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical significance of serum low-density lipoprotein receptor-related protein 6 (LRP6) level in patients with acute myocardial infarction (AMI).
Methods:One hundred and fifty patients with AMI were selected as the AMI group and 150 patients with suspected coronary heart disease without coronary artery stenosis were selected as control group from January 2017 to December 2018 in Quzhou People′s Hospital of Zhejiang. The serum LRP6 levels were determined by Western blot. The serum B-type brain natriuretic peptide (BNP) and cardiac troponin I (cTnI) levels were determined by enzyme-linked immunosorbent assay (ELISA).
Results:The levels of total cholesterol (TC), triglyceride (TG) and low-density lipoprotein cholesterol (LDL-C) in AMI group were higher than those in the control group [(4.42 ± 0.79) mmol/L vs. (3.79 ± 0.82) mmol/L, (1.52 ± 0.33) mmol/L vs. (1.37 ± 0.38) mmol/L, (3.15 ± 0.34) mmol/L vs. (2.91 ± 0.28) mmol/L], and the level of high-density lipoprotein cholesterol (HDL-C) was lower than that in control group [(0.95 ± 0.26) mmol/L vs. (1.21 ± 0.33) mmol/L], and there were significant differences (P<0.05). The level of serum LRP6 and left ventricular ejection fractionin in AMI group were lower than those in control group [0.12 ± 0.03 vs. 0.38 ± 0.07, (53.27 ± 6.89)% vs. (66.82 ± 7.35)%], and the BNP and cTnI levels were higher than those in control group [(78.16 ± 5.27) ng/L vs. (7.13 ± 1.24) ng/L, (125.83 ± 3.26) ng/L vs.(0.71 ± 0.24) ng/L], and there were significant differences (P<0.05). The serum LRP6 level was negatively correlated with LDL-C, BNP, cTnI and SYNTAX scores (r=- 0.587, - 0.523, - 0.542, - 0.583, P<0.05), and was positively correlated with left ventricular ejection fraction (r=0.515, P<0.05).
Conclusions:Serum LRP6 level is decreased in patients with AMI. Serum LRP6 is closely related to the severity of AMI and the extent of coronary artery disease.
