Clinical study of different frequency repetitive transcranial magnetic stimulation in the treatment of senile schizophrenia
10.3760/cma.j.issn.1673-4904.2020.02.001
- VernacularTitle: 不同频率重复经颅磁刺激治疗老年精神分裂症患者临床研究
- Author:
Wei LYU
1
;
Meihua LI
2
;
Chunyang LIU
2
;
Cheng ZHU
1
;
Ke ZHENG
3
Author Information
1. Department of Somatic Amalgamation, Kangning Hospital Affiliated to Wenzhou Medical University, Wenzhou 325000, China
2. Department of General Psychiatry, Kangning Hospital Affiliated to Wenzhou Medical University, Wenzhou 325000, China
3. Department of Behavioral Medicine, Kangning Hospital Affiliated to Wenzhou Medical University, Wenzhou 325000, China
- Publication Type:Journal Article
- Keywords:
Senile schizophrenia;
Elder;
Sex hormone;
Repetitive transcranial magnetic stimulation;
Cognitive function
- From:
Chinese Journal of Postgraduates of Medicine
2020;43(2):97-100
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the clinical study of different frequency repetitive transcranial magnetic stimulation in the treatment of senile schizophrenia.
Methods:The 70 elderly schizophrenics admitted to Kangning Hospital Affiliated to Wenzhou Medical University from February 2018 to August 2019 were randomly divided into observation group (35 cases) and control group (35 cases). High frequency repetitive transcranial magnetic stimulation was used in the observation group and low frequency repetitive transcranial magnetic stimulation was used in the control group. Both groups were treated for 4 weeks. The changes of clinical global impression (CGI), positive and negative syndrome scale (PANSS), cognitive function rating scale for schizophrenia (SCoRS), scale of social-skills for psychiatric inpatients(SSPI) and serum sex hormone levels before and after treatment were compared between the two groups.
Results:After treatment, the CGI and PANSS scores of the two groups were lower than those before treatment [observation group:(2.43 ± 0.37) scores vs. (5.61 ± 0.58) scores, (35.73 ± 6.57) scores vs. (79.95 ± 8.98) scores, t=27.346 and 23.512; control group: (3.37 ± 0.48) scores vs. (5.49 ± 0.62) scores, (40.91 ± 8.17) scores vs. (78.64 ± 9.63) scores, t=15.996 and 17.675, P<0.05]; after treatment, the CGI and PANSS scores of the observation group were lower than those of the control group (t=9.176, 2.923, P<0.05). After treatment, the SCoRS scores of the two groups was lower than those before treatment (observation group: t=12.822, control group: t=7.402, P<0.05); after treatment, the SCoRS score of the observation group was lower than that of the control group [(27.92 ± 5.41) scores vs. (34.25 ± 6.17) scores] (t=4.564, P<0.05). The SSPI scores of the two groups increased after treatment (observation group: t=9.252; control group: t=3.671, P<0.05); after treatment, the SSPI scores of the observation group were higher than those of the control group [(35.74 ± 3.27) scores vs. (30.85 ± 2.28) scores](t=7.257, P<0.05). After treatment, the serum testosterone and prolactin levels in the two groups were higher than those before treatment (observation group: t=13.853, 15.198; control group: t=10.075 and 9.225, P<0.05); after treatment, the serum testosterone and prolactin levels in the observation group were higher than those in the control group (t=5.693 and 7.202, P<0.05).
Conclusions:High frequency repetitive transcranial magnetic stimulation is superior to low frequency repetitive transcranial magnetic stimulation in the treatment of senile schizophrenia, and the improvement of sex hormone level is superior to low frequency repetitive transcranial magnetic stimulation, and the improvement of cognitive and social functions is superior to low frequency repetitive transcranial magnetic stimulation.
