Research progress of tetanus antibody detection technology in China
10.3760/cma.j.issn.0253-9624.2020.02.021
- VernacularTitle: 中国破伤风抗体检测技术研究进展
- Author:
Chuanlin WANG
1
;
Ming LI
1
;
Xinjun LYU
2
Author Information
1. Trauma Center and Emergency Depratment, Peking University People′s Hospital, Beijing 100044, China
2. Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100052, China
- Publication Type:Review
- Keywords:
Tetanus toxoid;
Vaccine;
Antibody;
Enzyme-linked immunosorbent assay;
Colloidal gold
- From:
Chinese Journal of Preventive Medicine
2020;54(2):224-227
- CountryChina
- Language:Chinese
-
Abstract:
The situation of prevention of non-neonatal tetanus in China is severe. Strengthening the active immunization with tetanus toxoid vaccine (TTCV) is the key to prevent the non-neonatal tetanus. Through the detection of tetanus antibody (TAB), the immune status of individual can be determined, so as to implement the active immunization of TTCV correctly. The research on TAB detection technology is stagnant in aboard, but still in a development process in China since there is a realistic demand for TAB detection. This review collects relatively limited data of TAB detection technology in China, and summarizes the techniques such as mice toxin neutralization test (MTNT), indirect hemagglutination assay (IHA), double agar gel immune diffusion test (Rubin method), enzyme-linked immunosorbent assay (ELISA) and colloidal gold (CG), in order to provide a comprehensive basis for domestic TAB detection. The TAB detection technology in China has not yet achieved international recognition due to the lack of comparative study of domestic and international institutions and reference reagents. The special domestic situation of tetanus prevention makes the research of TAB detection technology have a certain practical significance, and rapid detection reagents such as ELISA and CG method have a certain application value in China.
