Meta-analysis of comparison for efficacies between surgical plus radio(chemo)therapy and non-surgery chemoradiotherapy treatment strategies for advanced hypopharyngeal cancer
10.3760/cma.j.issn.1673-0860.2020.02.011
- VernacularTitle: 晚期下咽癌手术综合疗法与非手术综合疗法两种治疗策略疗效比较的Meta分析
- Author:
Jiamin FAN
1
;
Shuxin WEN
2
;
Binquan WANG
3
;
Hui HUANGFU
3
;
Xuesong ZHAI
4
;
Xiaojuan ZHAO
4
Author Information
1. the First Clinical College of Shanxi Medical University, Taiyuan 030001, China（Fan Jiamin is working on the Department of Otorhinolaryngology Head and Neck Surgery, Datong Coal Mine Group General Hospital, Datong 037000, China）
2. Department of Otorhinolaryngology Head and Neck Surgery, the First Hospital of Shanxi Medical University, Taiyuan. 030001, China （Wen Shuxin is working on the Department of Otorhinolaryngology Head and Neck Surgery, Shenzhen University, General Hospital, Shenzhen 518055, China）
3. Department of Otorhinolaryngology Head and Neck Surgery, the First Hospital of Shanxi Medical University, Taiyuan. 030001, China
4. the First Clinical College of Shanxi Medical University, Taiyuan 030001, China
- Publication Type:Journal Article
- Keywords:
Hypopharyngeal neoplasms;
Surgical procedures, operative;
Radiotherapy;
Combined modality therapy;
Meta-analysis
- From:
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
2020;55(2):144-149
- CountryChina
- Language:Chinese
-
Abstract:
Objective:Meta-analysis was used to compare the long-term efficacy and laryngeal function preservation rate of patients with advanced hypopharyngeal cancer treated with surgery plus radio(chemo)therapy (SRT) or non-surgery chemoradiotherapy (CRT).
Methods:We searched publicly published articles on case-control studies of surgical and non-surgical comprehensive treatment of advanced hypopharyngeal cancer in PubMed, the Cochrane Library, Wanfang Database, Chinese Journal Full-text Database, and Chinese Science and Technology Periodical Database. The search language was limited to Chinese and English, and the period was from 1990 to 2018. These literatures were rigorously screened by inclusion and exclusion criteria. The data needed for this study were extracted and the Meta analysis was performed using RevMan 5.3 software.
Results:A total of 13 literatures were included, and the overall quality of the literature was relatively high, and no significant publication bias was suggested. A total of 1 994 subjects, including 720 in the SRT group and 1 274 in the CRT group. The average 3-year overall survival rates were 42.9% in SRT group and 44.8% in CRT group,with no significant difference (OR=1.14, 95%CI: 0.62-2.06, P=0.68). The average 5-year overall survival rate (OR=1.42, 95%CI: 1.10-1.84, P<0.01), 5-year local recurrence-free survival rate (OR=1.68, 95%CI: 1.11-2.55, P=0.01) and 5-year local control rate (OR=2.17, 95%CI: 1.52-3.12, P<0.01) of SRT group were 46.4%, 47.4% and 71.2%, respectively, which were higher than those of non-surgical group (37.9%, 32.0%, and 52.2% respectively). The average laryngeal function preservation rate was 19.8%,being significantly lower than 80.6% of the non-surgical group(OR=0.03, 95%CI: 0.01-0.07, P<0.01).
Conclusions:SRT has better long-term efficacy, while CRT has better preservation of laryngeal function.
