Advances in the research of the relationship between skin regulatory T cells and wound healing and immune diseases
10.3760/cma.j.issn.1009-2587.2020.02.015
- VernacularTitle: 皮肤调节性T细胞与创面愈合及免疫疾病的关系研究进展
- Author:
Yuewen XIN
1
;
Yanfen CHAI
1
;
Yongming YAO
2
Author Information
1. Emergency Department of General Hospital, Tianjin Medical University, Tianjin 300052, China
2. Trauma Research Center, the Fourth Medical Center of PLA General Hospital, Beijing 100048, China
- Publication Type:Review
- Keywords:
Skin;
Wound healing;
Immunity;
Regulatory T cells;
Immune characteristics
- From:
Chinese Journal of Burns
2020;36(2):156-160
- CountryChina
- Language:Chinese
-
Abstract:
As the body′s largest organ, skin harbors a large amount of immune cells to regulate both innate and adaptive immune responses. Regulatory T cells (Tregs), as a subset of T lymphocytes with negative regulatory functions, play an important role in maintaining the immune homeostasis of different tissue. However, researches of skin Tregs are largely limited and uncompleted as compared with other tissue. In recent years, a comprehensive understanding is increasingly showing the specialized functions of Tregs in skin, including the orchestration of tissue wound healing, involvement in hair follicle recycling, and modulation of proper immune homeostasis. In this review, we outline the classification and characteristics of Tregs in skin, distribution, migration routes, immune effects, and relationship with wound healing, which aims to deepening our understanding towards the immunological effects of T lymphocytes subsets in skin and its regulatory pathways.
