Circulating tumor cell detection approaching to clinical application
10.3760/cma.j.issn.1009-9158.2020.02.003
- VernacularTitle: 循环肿瘤细胞检测走近临床
- Author:
Zhen CAI
1
;
Lei ZHENG
1
;
Jingping LIU
2
;
Shiyang PAN
2
Author Information
1. Department of Laboratory Medicine, NanFang Hospital, Southern Medical University, Guangzhou 510515, China
2. Department of Laboratory Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
- Publication Type:Journal Article
- Keywords:
Neoplastic cells, circulating;
Liquid biopsy;
Genetic heterogeneity;
Reference standards;
Biomarkers, tumor
- From:
Chinese Journal of Laboratory Medicine
2020;43(2):111-114
- CountryChina
- Language:Chinese
-
Abstract:
As "seeds" of tumor metastasis, circulating tumor cell (CTC) has important clinical application value in early diagnosis, immunotherapy and prognosis evaluation of tumors. With a deep understanding of CTC, its applied research has switched from cell enumeration to the molecular typing and single-cell sequencing. However, the standardization of CTC detection is still at a primary stage, opportunities and challenges coexist. This paper will review the current status and challenges in clinical applications of CTC detection, and make some suggestions for future development.
