Research progress on radiation-resistant and radiation-sensitive proteomics in glioma stem cells
10.3760/cma.j.issn.1004-4221.2020.02.016
- VernacularTitle: 胶质瘤干细胞放射抗拒和放射增敏蛋白质组学研究进展
- Author:
Shanshan ZHANG
1
;
Yuntian SHEN
1
;
Qiuhong FAN
1
;
Ye TIAN
1
;
Qiang HUANG
2
Author Information
1. Department of Radiotherapy, Second Affiliated Hospital of Soochow University, Suzhou 215004, China
2. Department of Neurosurgery, Second Affiliated Hospital of Soochow University, Suzhou 215004, China
- Publication Type:Review
- Keywords:
Gioma stem cell;
Radiation sensitivity;
Proteomics
- From:
Chinese Journal of Radiation Oncology
2020;29(2):150-153
- CountryChina
- Language:Chinese
-
Abstract:
After multidisciplinary treatment including radiotherapy, the median survival of patients with glioblastoma multiforme (GBM) remains approximately 1 year. The heterogeneity of the genome and proteome of glioblastoma stem cells (GSC) is the fundamental factor affecting the prognosis. Proteomics-based sensitization of key radioresistance proteins is expected to improve the prognosis of GBM patients. In this article, literature review was conducted from PubMed and other databases in the previous 10 years to systematically discuss the research progress on various commonly used protein quantitative techniques, tools for data processing analysis and the application in radioresistance and radiosensitization of GSCs.
