A correlative study of liver fat content and bone mineral density in middle-aged and elderly people
10.3760/cma.j.issn.1005-1201.2020.02.009
- VernacularTitle: 中老年人群肝脏脂肪含量与骨密度的相关性研究
- Author:
Chenxin ZHANG
1
;
Xiaoguang CHENG
1
;
Li XU
1
;
Ling WANG
1
;
Yong ZHANG
2
;
Yangyang DUANMU
3
;
Tianyu ZHANG
4
;
Haisong ZHANG
4
Author Information
1. Department of Radiology, Beijing Jishuitan Hospital, Beijing 100035, China
2. Department of Intervention, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China
3. Department of Radiology, Anhui Provincial Hospital, Hefei 230001, China
4. Department of Radiology, Hospital of Qinghe Branch of Beijing Prison Administration, Beijing 300481, China
- Publication Type:Journal Article
- Keywords:
Fatty liver;
Bone density;
Tomography, X-ray computed;
mDIXON-Quant technique
- From:
Chinese Journal of Radiology
2020;54(2):136-139
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the quantitative relationship between liver fat content and bone mineral density (BMD) in middle-aged and elderly people.
Methods:Totally 184 middle-aged and elderly community residents were recruited from March to June 2016, including 68 males and 116 females. MRI mDIXON-Quant and quantitative CT (QCT) examinations were performed to determine the content of liver fat and L1-L3 vertebral BMD. The subjects were divided into four groups according to the quartiles of liver fat content, and the baseline characteristics and other variables of different groups were were identified by using one-way analysis of Variance. The relationship between liver fat content and lumbar vertebral BMD was assessed with Spearman correlation and partial correlation analysis.
Result:Subjects with higher hepatic fat content had lower spine BMD and higher body mass index (BMI), waist circumference. Liver fat content was negatively correlated with BMD (r=-0.203, P=0.003). After age and body weight were controlled, the negative correlation between liver fat content and BMD was still significant (r=-0.291, P<0.001), in males (r=-0.283, P=0.021) and in females (r=-0.210, P=0.025).
Conclusion:Liver fat content is negatively correlated with lumbar vertebral BMD in middle-aged and elderly people.
