The efficacy of gradeⅡ glioma with postoperative intensity modulated radiotherapy
10.3760/cma.j.issn.0254-5098.2020.02.007
- VernacularTitle: Ⅱ级胶质瘤术后调强放射治疗疗效分析
- Author:
Shan LI
1
;
Xuezheng WANG
2
;
Yanbin CHEN
1
;
Zanyi WU
3
;
Hairong ZHANG
4
;
Jiang ZENG
1
;
Chuanshu CAI
1
;
Weijian ZHANG
1
;
Li SU
1
;
Jinsheng HONG
1
Author Information
1. Department of Radiation Oncology, First Affiliated Hospital of Fujian Medical University, Fujian Key Laboratory of Individualized Active Immunotherapy, Key Laboratory of Radiation Biology (Fujian Medical University), Fuzhou 350005, China
2. First Clinical Medical College of Fujian Medical University, Fuzhou 350005, China
3. Department of Neurosurgery, First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China
4. Provincial Center for Disease Control and Prevention, Fuzhou 350005, China
- Publication Type:Journal Article
- Keywords:
Grade Ⅱ glioma;
Intensity modulated radiotherapy;
Efficacy;
Prognosis
- From:
Chinese Journal of Radiological Medicine and Protection
2020;40(2):112-115
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To retrospectively analyze the efficacy and prognostic factors of postoperative intensity modulated radiotherapy for grade Ⅱ gliomas.
Methods:Retrospective analysis was conducted on patients with postoperative grade Ⅱ glioma in our hospital from Jan. 2010 to Dec. 2018. The primary endpoint was progression-free survival, and the secondary endpoint was overall survival. Correlative analyses of prognosis by age, gender, initial resection status, the maximum diameter of the lesions, bi-hemisphere, astrocytoma, chemoradiation, adjuvant chemotherapy were conducted.
Results:A total of 109 cases with grade Ⅱ glioma were enrolled. The follow-up rate was 91.75%, including 10 cases dead and 27 relapsed. There were 24 cases (88.9%) of in-field failure, and 3 cases (11.1%) of out-field failure. 14 cases of recurrence occurred in 81 cases of total resection group, accounting for 17.3%, and 13 in 28 cases of subtotal resection group, accounting for 46.4%. The recurrence rate in the subtotal resection group was significantly higher than that in the total resection group (χ 2=9.484, P<0.05). The 1-, 2-, 3-, 4- and 5-year progression-free survival rates were 92.5%, 86.0%, 80.6%, 77.5% and 66.8%, respectively. The 2-, 3-, 4- and 5-year overall survival rates were 97.2%, 90.8%, 87.7% and 84.5%, respectively. Multivariate analysis showed that patients with subtotal resection(HR=3.608, P<0.05) and bi-hemisphere(HR=3.183, P<0.05)were significantly correlated with the progression free survival.
Conclusions:Postoperative intensity modulated radiotherapy for grade Ⅱ gliomas can achieve a better PFS. Recurrence in the radiation field is the main failure mode. Initial resection status and bi-hemisphere of tumor are important influential factors for PFS of grade Ⅱ gliomas patients.
