Comparison of short-term and long-term outcomes between thoracoscopic pneumonectomy and open pneumonectomy for non-small cell lung cancer: a study based on propensity score matching
10.3760/cma.j.issn.0529-5815.2020.02.011
- VernacularTitle: 基于倾向性评分匹配的胸腔镜与开放全肺切除术治疗非小细胞肺癌的近期及远期疗效比较
- Author:
Xiaokang GUO
1
;
Huijiang GAO
1
;
Maolong WANG
1
;
Bin HAN
1
;
Bin WANG
2
;
Nan GE
1
;
Guodong SHI
1
;
Yucheng WEI
1
Author Information
1. Department of Thoracic Surgery, the Affiliated Hospital of Qingdao University, Qingdao 266000, China
2. Department of Thoracic Surgery, Changyi People′s Hospital, Changyi 261300, Shandong Province, China
- Publication Type:Journal Article
- Keywords:
Carcinoma, non-small-cell lung;
Pneumonectomy;
Thoracoscopy;
Treatment outcome;
Propensity score matching
- From:
Chinese Journal of Surgery
2020;58(2):131-136
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare the short-term and long-term results of thoracoscopic and open pneumonectomy for non-small cell lung cancer.
Methods:The clinical data of patients with non-small cell lung cancer who underwent pneumonectomy in the Department of Thoracic Surgery, Qingdao University Hospital from January 2008 to December 2016 were collected. Totally 142 patients (55 in the thoracoscopic group and 87 in the open group) were included in the study. A total of 29 pairs of patients were successfully matched by propensity score matching (PSM). Perioperative outcomes and overall survival were compared between the two groups using t test, χ2 test, Kaplan-Meier curve and Log-rank test, respectively.
Results:Camparion with open group, the thoracoscopic group had longer operative time ((209.7±70.2) minutes vs. (171.3±43.5) minutes, t=2.50, P=0.02), more mediastinal lymph node dissection (M(QR): 17(9) vs. 11(10), W=388, P=0.02) and shorter postoperative hospital stay (7.0(3.5) vs. 9.0(3.0), W=285, P=0.03). There was no significant difference in estimated blood loss, postoperative drainage time, dissected lymph node number, dissected lymph node station and perioperative complications. After PSM, there were no signifificant differences found in 3-year survival (71.4% vs. 48.1%, P=0.10) and 3-year disease-free survival (67.4% vs. 47.2%, P=0.13) between the two groups.
Conclusion:Thoracoscopic pneumonectomy is safe and feasible for the treatment of non-small cell lung cancer with more mediastinal lymph node dissection and accelerating recovery, and equivalent long-term prognosis when compared with open approach.
