Association of NLRP2 gene polymorphisms with type 1 diabetes mellitus in Chinese Han population
- VernacularTitle: NLRP2基因多态性与中国汉族人群1型糖尿病的关联研究
- Author:
Xiaoxiao SUN
1
;
Ying XIA
1
;
Linling XU
1
;
Shuoming LUO
1
;
Jian LIN
1
;
Yang XIAO
1
;
Xia LI
1
;
Gan HUANG
1
;
Zhiguo XIE
1
;
Zhiguang ZHOU
1
Author Information
- Publication Type:Clinical Trail
- Keywords: Diabetes mellitus, type 1; NLRP2 gene; Polymorphism, single nucleotide
- From: Chinese Journal of Endocrinology and Metabolism 2020;36(2):111-115
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the association between NLRP2(NLR Family Pyrin Domain Containing 2) gene polymorphisms and classical type 1 diabetes mellitus(T1DM) in Chinese Han population.
Methods:A case-control study was conducted in 510 classical T1DM patients from the Department of Metabolism and Endocrinology in the Second Xiangya Hospital affiliated to Central South University and 531 healthy controls in this region. The polymorphisms of rs1043673 in NLRP2 gene were analyzed by MassARRAY.Mann -Whitney U test andχ 2 test were used to compare the differences between patients and controls.Logistic regression analysis andχ 2 test were performed to compare the distributions of the alleles and genotypes between T1DM patients and controls.Kruskal -Wallis H test was used to compare the clinical characteristics of different genotypes in T1D patients.
Results:The differences of the allele and genotype distributions in rs1043673 of NLRP2 gene were not significant between patients and controls. The polymorphisms of rs1043673 were associated with fasting C-peptide(P =0.029), postprandial 2-h C-peptide(P =0.017), and titer of GADA(P =0.043) in T1DM patients.
Conclusion:The polymorphisms of NLRP2 gene were associated with the characteristics of T1DM patients.
