Comparison of intranasal dexmedetomidine and oral chloral hydrate administration for deep sedation in children: a meta-analysis
10.3760/cma.j.issn.1671-7368.2020.02.007
- VernacularTitle: 右美托咪定滴鼻与水合氯醛口服对小儿中深度镇静效果比较的Meta分析
- Author:
Tianliang HOU
1
;
Long YANG
;
Yewei ZHU
;
Yanhua WANG
;
Chunling CHEN
Author Information
1. Department of Anesthesiology, the First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China
- Publication Type:Journal Article
- Keywords:
Chloral hydrate;
Dexmedetomidine;
Meta-analysis;
Children, medium and deep sedation;
Randomized controlled trial
- From:
Chinese Journal of General Practitioners
2020;19(2):122-126
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare the effect of intranasal dexmedetomidine and oral chloral hydrate in deep sedation of children.
Methods:The Pubmed, EMBase, CENTRAL (Issue 4, 2018), Web of science, CBM, Wanfang Data, CNKI and VIP databases from the inception to January 2019 were searched. Randomized controlled trials (RCTs) with dexmedetomidine and chloral hydrate as interventions were included and the data were analyzed by RevMam 5.3 and Stata 12.0 software. The success rate of deep sedation, the indicator of sedation onset time, the recovery time, the incidence of vomiting and bradycardia were compared.
Results:A total of 7 RCTs involving 1 007 patients were included for analysis. The results showed that the success rate of deep sedation (OR=2.55, 95%CI:1.46-4.44, P<0.01) and the incidence of bradycardia (OR=4.42, 95%CI:1.82-10.74, P<0.01) in the dexmedetomidine nasal group were significantly higher than those in the chloral hydrate oral group. The recovery time was significantly shorter (MD=-16.41, 95%CI:-21.54-11.28, P<0.01) and the incidence rate of vomiting (OR=0.04, 95%CI:0.01-0.17, P<0.01) in dexmedetomidine nasal group was significantly lower than those in the chloral hydrate oral group. There was no significant difference in the indicator of sedation onset time (MD=-0.47, 95%CI:-2.71-1.22, P=0.46).
Conclusion:Compared with the traditional oral chloral hydrate, intranasal dexmedetomidine has a higher sedation success rate and shorter recovery time after sedation with a lower incidence of nausea and vomiting.
